Fast Electrical Detection of Carcinoembryonic Antigen Based on AlGaN/GaN High Electron Mobility Transistor Aptasensor
Xiang-Mi Zhan1, Quan Wang1, Kun Wang1, Wei Li1, Hong-Ling Xiao1,2,3, Chun Feng1,3, Li-Juan Jiang1,3, Cui-Mei Wang1,2,3, Xiao-Liang Wang1,2,3**, Zhan-Guo Wang1,3
1Key Lab of Semiconductor Materials Science, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083 2School of Microelectronics, University of Chinese Academy of Sciences, Beijing 100049 3Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices, Beijing 100083
Abstract：As one of the most important tumor-associated antigens of colorectal adenocarcinoma, the carcinoembryonic antigen (CEA) threatens human health seriously all over the globe. Fast electrical and highly sensitive detection of the CEA with AlGaN/GaN high electron mobility transistor is demonstrated experimentally. To achieve a low detection limit, the Au-gated sensing area of the sensor is functionalized with a CEA aptamer instead of the corresponding antibody. The proposed aptasensor has successfully detected different concentrations (ranging from 50 picogram/milliliter (pg/ml) to 50 nanogram/milliliter (ng/ml)) of CEA and achieved a detection limit as low as 50 pg/ml at $V_{\rm ds}=0.5$ V. The drain-source current shows a clear increase of 11.5 $\mu$A under this bias.
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2017, Vol. 34 
