| CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
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Monte Carlo Simulation on Growth of Antibody-Antigen Complexes: the Role of Unequal Reactivity |
| ZHANG Ping1,2, WANG Hai-Jun1,3,4 |
| 1College of Chemistry and Environment Science, Hebei University, Baoding 071002 2Department of Biomedical Engineering, Chengde Medical College, Chengde 067000 3International Centre for Materials Physics, Chinese Academy of Sciences, Shenyang 110016 4Key Laboratory of Medical Chemistry and Molecular Diagnosis (Ministry of Education), Hebei University, Baoding 071002 |
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| Cite this article: |
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ZHANG Ping, WANG Hai-Jun 2010 Chin. Phys. Lett. 27 038701 |
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Abstract Growth of Antibody-Antigen complexes in a multivalent Antibody-Antigen system is studied by the Monte Carlo simulation method. The validity of the algorithm is first demonstrated for the case of the equal reactivity, then the simulation is presented for the case of unequal reactivity. It is shown that the influence of the unequal reactivity on the critical point, size distribution and the weight-average binding degree is significant. Especially, the gelation regions for the cases of unequal reactivity are studied, which can provide some useful clues for the immunological experiments.
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| Keywords:
87.10.Rt
82.39.-k
87.15.-v
82.30.Nr
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Received: 12 May 2009
Published: 09 March 2010
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| PACS: |
87.10.Rt
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(Monte Carlo simulations)
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82.39.-k
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(Chemical kinetics in biological systems)
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87.15.-v
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(Biomolecules: structure and physical properties)
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82.30.Nr
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(Association, addition, insertion, cluster formation)
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