| CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
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Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells |
| LI Cong-Xin, CHEN Xiao-Fang, WANG Peng-Ye, WANG Wei-Chi |
| Laboratory of Soft Matter Physics, Beijing National Laboratory for CondensedMatter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190 |
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| Cite this article: |
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LI Cong-Xin, CHEN Xiao-Fang, WANG Peng-Ye et al 2010 Chin. Phys. Lett. 27 028701 |
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Abstract A reaction-diffusion model is built to investigate the temporal and spatial patterns of cytoplasmic Ca2+ dynamics under the effects of Ca2+-release activated Ca2+ (CRAC) channels in T cells. Simulation results show a strong dependence of the modulation mode of Ca2+ oscillation and dynamic patterns of Ca2+ wave on the influx rate through the CRAC channel (ksoc). When ksoc is small, cytoplasmic Ca2+ is modulated as a frequency-modulation (FM) signal, whereas it shows an amplitude modulation (AM) mode after ksoc passes through a critical value. The heterogeneity in spatial Ca2+ distribution is mostly arising from the influx through CRAC channels in both FM and AM modes. During each Ca2+ spike, a more sustained cytoplasmic Ca2+ gradient is maintained in the AM mode rather than in the FM mode.
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87.16.Xa
87.16.dj
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Received: 23 October 2009
Published: 08 February 2010
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| PACS: |
87.16.Xa
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(Signal transduction and intracellular signaling)
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(Dynamics and fluctuations)
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87.16.Vy
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(Ion channels)
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(Theory, modeling, and simulations)
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