| CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
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Numerical Simulations of Calcium Ions Spiral Wave in Single Cardiac Myocyte |
BAI Yong-Qiang1, ZHU Xing2,3 |
| 1College of Electronic Science, Daqing Petroleum Institute,Daqing 1633182School of Physics, State Key Laboratory for Artificial Microstructureand Mesoscopic Physics, Peking University, Beijing 1008713National Center for Nanoscience and Technology, Beijing 100080 |
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| Cite this article: |
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BAI Yong-Qiang, ZHU Xing 2010 Chin. Phys. Lett. 27 048201 |
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Abstract The calcium ions (Ca2+) spark is an elementary Ca2+ release event in cardiac myocytes. It is believed to buildup cell-wide Ca2+ signals, such as Ca2+ transient and Ca2+ wave, through a Ca2+-induced Ca2+ release (CICR) mechanism. Here the excitability of the Ca2+ wave in a single cardiac myocyte is simulated by employing the fire-diffuse-fire model. By modulating the dynamic parameters of Ca2+ release and re-uptake channels, we find three Ca2+ signaling states in a single cardiac myocyte: no wave, plane wave, and spiral wave. The period of a spiral wave is variable in the different regimes. This study indicates that the spiral wave or the excitability of the system can be controlled through micro-modulation in a living excitable medium.
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| Keywords:
82.39.Rt
87.16.Xa
89.75.Kd
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Received: 28 December 2009
Published: 27 March 2010
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| PACS: |
82.39.Rt
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(Reactions in complex biological systems)
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87.16.Xa
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(Signal transduction and intracellular signaling)
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89.75.Kd
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(Patterns)
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