Chin. Phys. Lett.  2018, Vol. 35 Issue (11): 118701    DOI: 10.1088/0256-307X/35/11/118701
CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
Effect of Torsion on Cisplatin-Induced DNA Condensation
Bo Li1,2†, Chao Ji3†, Xi-Ming Lu1,2, Yu-Ru Liu1, Wei Li1, Shuo-Xing Dou1,2, Hui Li1**, Peng-Ye Wang1,2**
1National Laboratory for Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190
2School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049
3School of Bioscience and Biotechnology, Weifang Medical University, Weifang 261053
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Bo Li, Chao Ji, Xi-Ming Lu et al  2018 Chin. Phys. Lett. 35 118701
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Abstract We investigate the effect of torsion on DNA condensation with the covalently closed circular DNA as the torsion-constrained system, using an atomic force microscope. It is found that there are two stages in the DNA condensation process under torsional constraint. At the early stage, the low torsion will accelerate DNA condensation by promoting the formation of micro-loops or intersection structures; while at the later stage, the increasing torsion will slow it down by preventing the crosslinking of cisplatin and DNA since the DNA molecule becomes more rigid. Our results show the important role of torsion in DNA condensation and sheds new light on the mechanism for DNA condensation.
Received: 25 July 2018      Published: 23 October 2018
PACS:  87.14.gk (DNA)  
  87.64.Dz (Scanning tunneling and atomic force microscopy)  
  87.10.Pq (Elasticity theory)  
Fund: Supported by the National Natural Science Foundation of China under Grant Nos 11674383, 11774407 and 11874415, the Key Research Program of Frontier Sciences of Chinese Academy of Sciences under Grant No QYZDB-SSW-SLH045, the National Key Research and Development Program under Grant No 2016YFA0301500, the Higher Educational Science and Technology Program of Shandong Province under Grant No J16LM06, the Natural Science Foundation of Shandong Province under Grant No ZR2014AQ025, and the Program of Shandong Provincial Government International Exchanges.
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https://cpl.iphy.ac.cn/10.1088/0256-307X/35/11/118701       OR      https://cpl.iphy.ac.cn/Y2018/V35/I11/118701
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Bo Li
Chao Ji
Xi-Ming Lu
Yu-Ru Liu
Wei Li
Shuo-Xing Dou
Hui Li
Peng-Ye Wang
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