Chin. Phys. Lett.  2016, Vol. 33 Issue (01): 018702    DOI: 10.1088/0256-307X/33/1/018702
CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
Nanomechanical Properties of Amyloid Fibrils Formed in a Water Nanofilm on Mica Surface
Lan-Jie Wang1, Li-Xia Kong1, Lan-Lan Su1, Zi-Qi Zhao1, Gong-Jun Zhang2, Xing-Fei Zhou1**
1School of Science, Ningbo University, Ningbo 315211
2Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201
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Lan-Jie Wang, Li-Xia Kong, Lan-Lan Su et al  2016 Chin. Phys. Lett. 33 018702
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Abstract

The assessment of nanomechanical properties of a single amyloid fibril in a confined space provides important information for understanding the role of fibrils in a cell microenvironment. In this study, the structure and nanomechanical properties of different fibrils formed in water nanofilms on mica surface are carefully investigated by using the new atomic force microscopy imaging mode-peak force quantitative nanomechanics (PF-QNM). We find that two types of fibrils with different morphologies are formed in water nanofilm on mica. The compression elasticities of these two types of fibrils are 3.9$\pm$0.9 and 2.5$\pm$0.6 GPa, respectively. The remarkable difference is possibly due to the structural discrepancy in two types of fibrils.

Received: 02 November 2015      Published: 29 January 2016
PACS:  87.14.em (Fibrils (amyloids, collagen, etc.))  
  62.20.de (Elastic moduli)  
  68.37.Ps (Atomic force microscopy (AFM))  
  87.15.La (Mechanical properties)  
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https://cpl.iphy.ac.cn/10.1088/0256-307X/33/1/018702       OR      https://cpl.iphy.ac.cn/Y2016/V33/I01/018702
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Lan-Jie Wang
Li-Xia Kong
Lan-Lan Su
Zi-Qi Zhao
Gong-Jun Zhang
Xing-Fei Zhou

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