| CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
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Single-Step Fabrication of Gd2O3@SiO2 Nanoparticles for use as MRI Contrast Agents by Pulsed Laser Ablation in Liquid |
| LUO Ning-Qi1, HUANG Zhan-Yun1, LI Li2, SHAO Yuan-Zhi1, CHEN Di-Hu1** |
1State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-sen University, Guangzhou 510275
2State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, Guangzhou 510080
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| Cite this article: |
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LUO Ning-Qi, HUANG Zhan-Yun, LI Li et al 2013 Chin. Phys. Lett. 30 038101 |
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Abstract Gd2O3@SiO2 nanoparticles with a core-shell structure are synthesized by pulsed laser ablation in liquid (PLAL) in single steps. A Gd2O3 target immersed in tetraethyl orthosilicate (TEOS) is ablated by a microsecond Nd:YAG laser, which induces the generation of a Gd2O3 plasma plume and pyrolysis of the TEOS. We propose that the moment Gd2O3 nanoparticles are formed they will be coated immediately by SiO2 and directly synthesized Gd2O3@SiO2 core-shell nanoparticles. These particles obtain high r1 relaxivity of 5.26 s?1mM?1 and are used as T1-weighted magnetic resonance imaging contrast agents. It is shown that the PLAL technique is promising for fabricating core-shell structure nanomaterial with potential medical applications.
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Received: 16 November 2012
Published: 29 March 2013
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