The Dynamical Mechanisms of the Cell Cycle Size Checkpoint

doi:10.1088/0256-307X/29/10/108701

Chin. Phys. Lett.

2012, Vol. 29

Issue (10): 108701 DOI: 10.1088/0256-307X/29/10/108701

CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY

The Dynamical Mechanisms of the Cell Cycle Size Checkpoint

FENG Shi-Fu¹, YAN Jie², LIU Zeng-Rong³, YANG Ling^1,2

¹School of Mathematical Sciences, Soochow University, Suzhou 215006
²Center for Systems Biology, Soochow University, Suzhou 215006
³Institute of Systems Biology, Shanghai University, 99 Shangda Road, Shanghai 200444

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FENG Shi-Fu, YAN Jie, LIU Zeng-Rong et al 2012 Chin. Phys. Lett. 29 108701

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Abstract Cell division must be tightly coupled to cell growth in order to maintain cell size, whereas the mechanisms of how initialization of mitosis is regulated by cell size remain to be elucidated. We develop a mathematical model of the cell cycle, which incorporates cell growth to investigate the dynamical properties of the size checkpoint in embryos of Xenopus laevis. We show that the size checkpoint is naturally raised from a saddle-node bifurcation, and in a mutant case, the cell loses its size control ability due to the loss of this saddle-node point.

Received: 26 July 2012 Published: 01 October 2012

PACS:	87.17.Aa	(Modeling, computer simulation of cell processes)
	87.17.Ee	(Growth and division)
	87.18.Mp	(Signal transduction networks)

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https://cpl.iphy.ac.cn/10.1088/0256-307X/29/10/108701 OR https://cpl.iphy.ac.cn/Y2012/V29/I10/108701

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	FENG Shi-Fu
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	YANG Ling

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