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Real-Time Measurements and Modelling on Dynamic Behaviour of SonoVue Bubbles Based on Light Scattering Technology |
| TU Juan1,2;GUAN J. F.2;MATULA T. J.2;Crum L. A.2;WEI Rongjue1 |
| 1Key Laboratory of Modern Acoustics (Ministry of Education), Nanjing University, Nanjing 2100932Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA, 98105, USA |
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| Cite this article: |
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TU Juan, GUAN J. F., MATULA T. J. et al 2008 Chin. Phys. Lett. 25 172-175 |
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Abstract The dynamic behaviour of SonoVue microbubbles, a new generation ultrasound contrast agent, is investigated in real time with light scattering method. Highly diluted SonoVue microbubbles are injected into a diluted gel made of xanthan gum and water. The responses of individual SonoVue bubbles to driven ultrasound pulses are measured. Both linear and nonlinear
bubble oscillations are observed and the results suggest that SonoVue microbubbles can generate strong nonlinear responses. By fitting the experimental data of individual bubble responses with Sarkar's model, the shell coating parameter of the bubbles and dilatational viscosity is estimated to be 7.0 nm·s·Pa.
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43.25.Yw
43.55.Wa
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Received: 23 May 2007
Published: 27 December 2007
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