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Protein Folding under Mediation of Ordering Water: an Off-Lattice Go--Like Model Study |
| ZUO Guang-Hong 1,2;HU Jun 1,3;FANG Hai-Ping 1,2 |
| 1Shanghai Institute of Applied Physics, Chinese Academy of Sciences, PO Box 800-204, Shanghai 2018002T-Life Research Center, Fudan University, Shanghai 2004333Bio-X Life Science Research Center, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030 |
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| Cite this article: |
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ZUO Guang-Hong, HU Jun, FANG Hai-Ping 2007 Chin. Phys. Lett. 24 2426-2429 |
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Abstract Water plays an important role in the structure and function of biomolecules. Water confined at the nanoscale usually exhibits phenomena not seen in bulk water, including the ice-like ordering structure on the surfaces of many substrates. We investigate the behaviour of protein folding in which the proteins are assumed in an environment with ordering water by using of an
off-lattice Go--like model. It is found that in the physiological temperature, both the folding rate and the thermodynamic stability of the protein are greatly promoted by the existence of ordering of water.
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| Keywords:
87.14.Ee
87.15.Cc
87.64.Aa
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Received: 13 June 2007
Published: 25 July 2007
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| PACS: |
87.14.Ee
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87.15.Cc
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(Folding: thermodynamics, statistical mechanics, models, and pathways)
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87.64.Aa
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(Computer simulation)
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