| GENERAL |
|
|
|
|
Enhancement of the Neuronal Dynamic Range by Proper Intensities of Channel Noise |
| WANG Lei, ZHANG Pu-Ming, LIANG Pei-Ji, QIU Yi-Hong** |
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240
|
|
| Cite this article: |
|
WANG Lei, ZHANG Pu-Ming, LIANG Pei-Ji et al 2013 Chin. Phys. Lett. 30 070506 |
|
|
|
|
Abstract The capability of a biological neuron to discriminate the intensity of external stimulus is measured in its dynamic range. In previous studies, a few factors have been reported to be able to enhance the dynamic range, e.g., electrical coupling and active dendrites. Here we numerically show that intrinsic channel noise within neurons has a subtle effect in neuronal dynamic range modulation. Our simulation results indicate that for relatively weak noise intensity, the dynamic range of the neuron is enhanced significantly. However, as the noise intensity becomes stronger, the dynamic range of the neuron is weakened. Further investigation suggests that sodium channel noise and potassium channel noise play opposite roles in modulating the dynamic range. Consequently, the model results suggest a new function of channel noise, that is, a proper value of noise intensity could optimize the dynamic range of neurons.
|
|
|
Received: 24 January 2013
Published: 21 November 2013
|
|
| PACS: |
05.40.-a
|
(Fluctuation phenomena, random processes, noise, and Brownian motion)
|
| |
87.19.ld
|
(Electrodynamics in the nervous system)
|
|
|
|
|
|
[1] Gollo L L, Mirasso C and Eguíluz V M 2012 Phys. Rev. E 85 040902
[2] Publio R, Oliveira R F and Roque A C 2009 PLoS One 4 e6970
[3] Gollo L L, Kinouchi O and Copelli M 2009 PLoS Comput. Biol. 5 e1000402
[4] Shew W L, Yang H, Petermann T, Roy R and Plenz D 2009 J. Neurosci. 29 15595
[5] White J A, Rubinstein J T and Kay A R 2000 Trends Neurosci. 23 131
[6] Schmid G, Goychuk I and H?nggi P 2004 Physica A 344 665
[7] Schneidman E, Freedman B and Segev I 1998 Neural Comput. 10 1679
[8] Fisch K, Schwalger T, Lindner B, Herz A V and Benda J 2012 J. Neurosci. 32 17332
[9] van Rossum M C, O'Brien B J and Smith R G 2003 J. Neurophysiol. 89 2406
[10] Rowat P 2007 Neural Comput. 19 1215
[11] Carelli P V, Reyes M B, Sartorelli J C and Pinto R D 2005 J. Neurophysiol. 94 1169
[12] Dorval A D and White J A 2005 J. Neurosci. 25 10025
[13] Schmid G, Goychuk I and H?nggi P 2003 Physica A 325 165
[14] Casado J M 2003 Phys. Lett. A 310 400
[15] H ?nggi P, Schmid G and Goychuk I 2002 Adv. Solid State Phys. 42 359
[16] Ashida G and Kubo M 2010 Physica D 239 327
[17] Liu S B, Wu Y, Hao Z W, Li Y J and Jia N 2012 Acta Phys. Sin. 61 020503 (in Chinese)
[18] Schmid G, Goychuk I and H ?nggi P 2006 Phys. Biol. 3 248
[19] Sun Z Q, Xie P, Li W and Wang P Y 2010 Chin. Phys. Lett. 27 088702
[20] Kang X S, Liang X M and Lü H P 2013 Chin. Phys. Lett. 30 018701
[21] Hodgkin A L and Huxley A F 1952 J. Physiol. 117 500
[22] Gan C B, Perc M and Wang Q Y 2010 Chin. Phys. B 19 040508
[23] Jin X and Liang P J 2006 Chin. Phys. Lett. 23 500
[24] Chen Y, Yu L and Qin S M 2008 Phys. Rev. E 78 051909
[25] Ozer M, Uzuntarla M, Perc M and Graham L J 2009 J. Theor. Biol. 261 83
[26] Kinouchi O and Copelli M 2006 Nat. Phys. 2 348
[27] Copelli M, Roque A C, Oliveira R F and Kinouchi O 2002 Phys. Rev. E 65 060901
[28] Stevens S S 1975 Psychophysics: Introduction to Its Perceptual, Neural and Social Prospects (New York: Wiley) |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
