| FUNDAMENTAL AREAS OF PHENOMENOLOGY(INCLUDING APPLICATIONS) |
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In Vivo Magnetic Particle Targeting by Local Gradient Field of Interstitial Seeds Magnetized in an Ex Vivo Uniform Field |
| LI Xiao-Qiang1,2, ZHENG Lu2, WANG Xu-Fei1,3** |
1Institute of Modern Physics, Fudan University, Shanghai 200433
2Department of Physics, Fudan University, Shanghai 200433
3Applied Ion Beam Physics Laboratory, Fudan University, Shanghai 200433
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| Cite this article: |
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LI Xiao-Qiang, ZHENG Lu, WANG Xu-Fei 2014 Chin. Phys. Lett. 31 024701 |
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Abstract The possibility of in vivo magnetic particle targeting by the locally induced gradient field of interstitial ferromagnetic implants, magnetized in an ex vivo uniform field, is evaluated by a modelling analysis. A simplified 3D model analogous to a torso size, with a continuous laminar flow through the volume with the typical velocity and viscosity values of in vivo blood flow and a ferromagnetic seed inserted in the volume center vertical to the flow, is used to evaluate the magnetic particle capturing efficiency by the seed, which is magnetized in a uniform field. The initial modelling results indicate that for 1–10 μm iron oxide particles transporting with a blood flow of 0.5–5 mm/s, the seeds of tungsten steel, magnet steel and cast cobalt all present an effective particle capturing efficiency, which shows a fast initial increase and a slow saturation with the increasing magnetic field, a quasilinear increase with the increasing particle size, and a nonlinear decrease with the increasing blood velocity.
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Received: 17 September 2013
Published: 28 February 2014
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| PACS: |
47.65.Cb
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(Magnetic fluids and ferrofluids)
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07.79.Pk
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(Magnetic force microscopes)
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75.50.Tt
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(Fine-particle systems; nanocrystalline materials)
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75.50.Mm
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(Magnetic liquids)
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