| FUNDAMENTAL AREAS OF PHENOMENOLOGY(INCLUDING APPLICATIONS) |
|
|
|
|
Quantitative Thermoacoustic Tomography for ex vivo Imaging Conductivity of Breast Tissue |
| HUANG Lin1, RONG Jian1, YAO Lei2, QI Wei-Zhi1, WU Dan1, XU Jin-Yu1, JIANG Hua-Bei1,2** |
1School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu 610054
2J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, U.S.A.
|
|
| Cite this article: |
|
HUANG Lin, RONG Jian, YAO Lei et al 2013 Chin. Phys. Lett. 30 124301 |
|
|
|
|
Abstract We assess the feasibility of our developed quantitative thermoacoustic tomography (qTAT) system for breast tumor characterization using mastectomy specimens before the clinical investigation. A circular scanning TAT system coupled with a finite-element based reconstruction algorithm is used to recover the dielectric property distribution of normal and tumor tissues from three female subjects who underwent mastectomy. Statistical method is used to analyze the tissue dielectric properties obtained. The recovered qTAT images reveal large contrast in conductivity between tumor and normal breast tissues. In addition, significant difference in conductivity exists among all the specimens examined. Finally, the recovered tumor size for these specimens agrees well with their exact size. This preclinical evaluation suggests that it is feasible to detect and characterize a breast tumor quantitatively with our qTAT method.
|
|
|
Received: 03 September 2013
Published: 13 December 2013
|
|
| PACS: |
43.35.+d
|
(Ultrasonics, quantum acoustics, and physical effects of sound)
|
| |
87.57.C-
|
(Image quality)
|
| |
43.60.+d
|
(Acoustic signal processing)
|
| |
43.80.+p
|
(Bioacoustics)
|
|
|
|
|
|
| [1] Jemal A, Bray F, Center M M, Ferlay J, Ward E and Forman D 2011 CA: A Cancer J. for Clinicians 61 69[2] Carney P A, Miglioretti D L, Yankaskas B C, Kerlikowske K, Rosenberg R, Rutter C M, Geller B M, Abraham L A, Taplin S H, Dignan M, Cutter G and Ballard-Barbash R 2003 Ann. Intern. Med. 138 168[3] Sickles E A, Miglioretti D L, Ballard-Barbash R, Geller B M, Leung J W, Rosenberg R D, Smith-Bindman R and Yankaskas B C 2005 Radiology 235 775[4] Boyd N F, Lockwood G A, Byng J W, Tritchler D L and Yaffe M J 1998 Breast Disease 10 113[5] Nass S J, Henderson I C and Lashof J C 2001 Mammography and Beyond: Developing Techniques for the Early Detection of Breast Cancer (Washington, D.C.: Inst. Med., Nat. Acad. Press)[6] Sabel M and Aichinger H 1996 Phys. Med. Biol. 41 315[7] Olsen R G 1982 Generation of Acoustic Images from the Absorption of Pulsed Microwave Energy, Acoustic Imaging ed J. P. Powers (New York: Plenum) pp 53–59[8] Lin J C and Chan K H 1984 IEEE Trans. Microwave Theory Tech. 32 854[9] Kruger R A, Reinecke D R and Kruger G A 1999 Med. Phys. 26 1832[10] Kruger R A, Kopecky K K, Aisen A M, Reinecke D R, Kruger G A and Kiser, Jr W L 1999 Radiology 211 275[11] Ku G and Wang L H 2001 Med. Phys. 28 4[12] Nie L M, Ou Z M, Yang S H and Xing D 2010 Med. Phys. 37 4193[13] Omar M, Kellnberger S, Sergiadis G, Razansky D and Ntziachristos V 2012 Med. Phys. 39 4460[14] Kruger R A, Miller K D, Reynolds H E, Kiser, Jr W L, Reinecke D R and Kruger G A 2000 Radiology 216 279[15] Pramanik M, Ku G, Li C H and Wang L H 2008 Med. Phys. 35 2218[16] Ke H X, Erpelding T N, Jankovic L, Liu C J and Wang L V 2012 J. Biomed. Opt. 17 056010[17] Ji Z, Lou C G, Yang S H and Xing D 2012 Med. Phys. 39 6738[18] Poplack S P, Paulsen K, Hartov A, Meaney P, Pogue B, Tosteson T, Grove M, Soho S and Wells W 2004 Radiology 231 571[19] Yao L, Guo G F and Jiang H B 2010 Med. Phys. 37 3752[20] Huang L, Yao L, Liu L X, Rong J and Jiang H B 2012 Appl. Phys. Lett. 101 244106[21] 2005 IEEE Standard for Safety Levels with Respect to Human Exposure to Radio Frequency Electromagnetic Fields, 3 kHz to 300 GHz IEEE Std C95.1[22] Campbell A M and Land D V 1992 Phys. Med. Biol. 37 193[23] Lazebnik M, Popovic D, McCartney L, Watkins C B, Lindstrom M J, Harter J, Sewall S, Ogilvie T, Magliocco A, Breslin T M, Temple W, Mew D, Booske J H, Okoniewski M and Hagness S C 2007 Phys. Med. Biol. 52 6093[24] Halter R J, Zhou T, Meaney P M, Hartov A, B Jr R J, Rosenkranz K M, Wells W A, Kogel C A, Borsic A, Rizzo E J and Paulsen K D 2009 Physiol. Meas. 30 S121[25] Sha L W, Ward E R and Stroy B 2002 Proc. IEEE Southeast Conference (Columbia USA 5–7 April 2002) p 457[26] Kircher M F, de la Zerda A, Jokerst J V, Zavaleta C L, Kempen P J, Mittra E, Pitter K, Huang R, Campos C, Habte F, Sinclair R, Brennan C C, Mellinghoff I K, Holland E C and Gambhir S S 2012 Nat. Med. 18 829 |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
