| CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
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Effect of Cisplatin on the Flexibility of Linear DNA |
| JI Chao, ZHANG Ling-Yun**, HOU Xi-Miao, DOU Shuo-Xing, WANG Peng-Ye***
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Key Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190
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JI Chao, ZHANG Ling-Yun, HOU Xi-Miao et al 2011 Chin. Phys. Lett. 28 068702 |
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Abstract With the aid of an atomic force microscope (AFM), we study the interaction between linear DNA fragment and cisplatin. For different cisplatin concentrations, the AFM used to observe the conformation of DNA has a gradual change. The contour length, the end-to-end distance and the local bend angles of the linear DNA fragment can be accurately measured. The persistence length of DNA interacting with cisplatin is decreased with the increasing cisplatin concentration. Furthermore, it is demonstrated that the local bend angles of DNA chains are increased by the binding interaction of cisplatin.
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| Keywords:
87.14.Gk
87.64.Dz
87.10.Pq
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Received: 12 January 2011
Published: 29 May 2011
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