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Stochastic Alternating Dynamics for Synchronous EAD-Like Beating Rhythms in Cultured Cardiac Myocytes |
ZHANG Ning, ZHANG Hui-Min, LIU Zhi-Qiang, DING Xue-Li, YANG Ming-Hao, GU
Hua-Guang, REN Wei |
| Brain and Behavior Institute, College of Life Science, Shaanxi Normal University, Xi'an 710062 |
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ZHANG Ning, ZHANG Hui-Min, LIU Zhi-Qiang et al 2009 Chin. Phys. Lett. 26 110501 |
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Abstract Dissolved cardiac myocytes can couple together and generate synchronous beatings in culture. We observed a synchronized early after-depolarization(EAD)-like rhythm in cultured cardiac myocytes and reproduced the experimental observation in a network mathematical model whose dynamics are close to a Hopf bifurcation. The mechanism for this EAD-like rhythm is attributed to noised-induced stochastic alternatings between the focus and the limit cycle. These results provide novel understandings for pathological heart rhythms like the early immature beatings.
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| Keywords:
05.45.Xt
87.19.Hh
87.18.Tt
87.18.Hf
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Received: 08 July 2009
Published: 30 October 2009
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| PACS: |
05.45.Xt
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(Synchronization; coupled oscillators)
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87.19.Hh
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(Cardiac dynamics)
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87.18.Tt
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(Noise in biological systems)
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87.18.Hf
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(Spatiotemporal pattern formation in cellular populations)
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