| CONDENSED MATTER: ELECTRONIC STRUCTURE, ELECTRICAL, MAGNETIC, AND OPTICAL PROPERTIES |
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Mechanism for Alternating Electric Fields Induced-Effects on Cytosolic Calcium |
| LUO Ming-Yan, SONG Kun, ZHANG Xu, LEE Imshik |
| Department of Biophysics, School of Physics, and Key Laboratory of Bioactive Materials (Ministry of Education), Nankai University, Tianjin 300071 |
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| Cite this article: |
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LUO Ming-Yan, SONG Kun, ZHANG Xu et al 2009 Chin. Phys. Lett. 26 017102 |
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Abstract In this work, from the point of calcium ions in the cytosol, we extend a Vm-[Ca2+]cyt model to explain the changes of action potential Vm of the plasma membrane and the calcium concentration in the cytosol [Ca2+]cyt under an alternating electric field in cells. An alternating external electric field may exert an oscillating force to each of the free electrolytes, existing on both sides of the plasma membrane. The mechanism for the alternating electric field induced-effects on Vm and [Ca2+]cyt is elucidated. The simulation results show a correlation between the changes of [Ca2+]cyt and the alternating electric field. When the numerical ratio between the intensity E0(mV/m) and the frequency υ (Hz) of the field was about 1-2, the [Ca2+]cyt signal is changed dramatically. The bioactive changes of [Ca2+]_cyt appear at low frequency, in the range of 0-100Hz.
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| Keywords:
71.15.Pd
82.20.Wt
82.20.Nk
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Received: 05 October 2008
Published: 24 December 2008
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| PACS: |
71.15.Pd
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(Molecular dynamics calculations (Car-Parrinello) and other numerical simulations)
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82.20.Wt
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(Computational modeling; simulation)
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82.20.Nk
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(Classical theories of reactions and/or energy transfer)
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