| CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
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Local Magnetic Nanoparticle Delivery in Microvasculature |
| GUO Ping1,2, LI Xin-Xia2, XIONG Ping1, HE Ji-Shan1 |
| 1School of Info-Physics and Geomatics Engineering, Central South University, Changsha 4100832Department of Nuclear Physics, University of South China, Hengyang 421001 |
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| Cite this article: |
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GUO Ping, LI Xin-Xia, XIONG Ping et al 2009 Chin. Phys. Lett. 26 018703 |
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Abstract The transport and capture of therapeutic magnetic nanoparticles in human microvasculature is studied numerically. The nanoparticles are injected into a vascular system upstream from malignant tissue, and are captured at the tumour site with the aid of a local applied magnetic field positioned outside the body. Taking into account the dominant magnetic and fluidic forces on the particles, our study shows that the nanoparticles can be directed to and concentrated at the desired zone that is within a few centimetres from the surface of the body. In addition, influence of the particles size, average blood flow velocity and the diameter of the blood vessel on the captured efficiency are parametrically analysed.
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| Keywords:
87.85.Cf
87.55.Ne
87.10.-e
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Received: 13 November 2008
Published: 24 December 2008
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