Chin. Phys. Lett.  2019, Vol. 36 Issue (8): 080305    DOI: 10.1088/0256-307X/36/8/080305
Quantum Approach to Fast Protein-Folding Time
Li-Hua Lu1, You-Quan Li1,2**
1Zhejiang Province Key Laboratory of Quantum Technology & Device, and Department of Physics, Zhejiang University, Hangzhou 310027
2Collaborative Innovation Center of Advanced Microstructure, Nanjing University, Nanjing 210008
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Li-Hua Lu, You-Quan Li 2019 Chin. Phys. Lett. 36 080305
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Abstract In the traditional random-conformational-search model, various hypotheses with a series of meta-stable intermediate states were proposed to resolve the Levinthal paradox in protein-folding time. Here we introduce a quantum strategy to formulate protein folding as a quantum walk on a definite graph, which provides us a general framework without making hypotheses. Evaluating it by the mean of first passage time, we find that the folding time via our quantum approach is much shorter than the one obtained via classical random walks. This idea is expected to evoke more insights for future studies.
Received: 26 July 2019      Published: 30 July 2019
PACS:  03.67.Ac (Quantum algorithms, protocols, and simulations) (Folding dynamics)  
  05.40.Fb (Random walks and Levy flights)  
Fund: Supported by National Key R&D Program of China under Grant No 2017YFA0304304, and partially by the Fundamental Research Funds for the Central Universities.
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