| FUNDAMENTAL AREAS OF PHENOMENOLOGY(INCLUDING APPLICATIONS) |
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Pharmacokinetic Monitoring of Indocyanine Green for Tumor Detection Using Photoacoustic Imaging |
YANG Si-Hua, YIN Guang-Zhi, XING Da |
| MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631 |
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| Cite this article: |
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YANG Si-Hua, YIN Guang-Zhi, XING Da 2010 Chin. Phys. Lett. 27 094302 |
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Abstract We report tumor detection using a photoacoustic technique for the imaging of angiogenesis and monitoring of agent pharmacokinetics on an animal model. We take 532-nm laser pulses to excite photoacoustic signals of blood vessels with acquisition by a broadband hydrophone, and the morphological characteristics of tumor angiogenesis are successfully image depicted. Furthermore, tumor pharmacokinetics is preformed and analyzed with fast multielement photoacoustic imaging of the intravenous-injected indocyanine green (ICG). Photoacoustic signals of ICG are excited with 805 nm laser pulses and recorded by transducer array as a function of time. The difference between the photoacoustic signal from the tumor side and that from the normal side is observed, and the ICG clearance velocity in the tumor area is found to lag behind that in the normal area. Experimental results demonstrate that photoacoustic imaging of morphological parameter and pharmacokinetics with specific agent may provide high sensitive approach for tumor detection and localization.
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43.35.Ud
42.62.Be
42.30.Wb
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Received: 29 April 2010
Published: 25 August 2010
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| PACS: |
43.35.Ud
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(Thermoacoustics, high temperature acoustics, photoacoustic effect)
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42.62.Be
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(Biological and medical applications)
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42.30.Wb
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(Image reconstruction; tomography)
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