Abstract：The possibility of in vivo magnetic particle targeting by the locally induced gradient field of interstitial ferromagnetic implants, magnetized in an ex vivo uniform field, is evaluated by a modelling analysis. A simplified 3D model analogous to a torso size, with a continuous laminar flow through the volume with the typical velocity and viscosity values of in vivo blood flow and a ferromagnetic seed inserted in the volume center vertical to the flow, is used to evaluate the magnetic particle capturing efficiency by the seed, which is magnetized in a uniform field. The initial modelling results indicate that for 1–10 μm iron oxide particles transporting with a blood flow of 0.5–5 mm/s, the seeds of tungsten steel, magnet steel and cast cobalt all present an effective particle capturing efficiency, which shows a fast initial increase and a slow saturation with the increasing magnetic field, a quasilinear increase with the increasing particle size, and a nonlinear decrease with the increasing blood velocity.
. [J]. 中国物理快报, 2014, 31(2): 24701-024701.
LI Xiao-Qiang, ZHENG Lu, WANG Xu-Fei. In Vivo Magnetic Particle Targeting by Local Gradient Field of Interstitial Seeds Magnetized in an Ex Vivo Uniform Field. Chin. Phys. Lett., 2014, 31(2): 24701-024701.
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2014, Vol. 31 
