The Diagnosis of Human Liver Cancer by using THz Fiber-Scanning Near-Field Imaging
CHEN Hua1** , MA Shi-Hua2 , YAN Wen-Xing1 , WU Xiu-Mei1 , WANG Xiao-Zhou1
1 Department of Physics, Southeast University, Nanjing 2100962 Institutes of THz Research, Electronic Science & Engineering, Southeast University, Nanjing 210096
Abstract :Based on a room-temperature-operated THz fiber-scanning near-field imaging system, we demonstrate the capability of THz imaging for diagnosing human liver cancer. By THz near-field mapping of the absorption constants of liver tissues, the acquired images can clearly distinguish cancer from normal tissues fast, automatically, and correctly without pathological H&E staining examination. Accordingly, the studied THz imaging system has valuable potential applications in clinical cancer diagnosis. With the help of THz imaging, we can expect to economize the use of hospital and human resources.
收稿日期: 2012-10-09
出版日期: 2013-03-29
[1] Ferguson B, Wang S, Gray D, Abbott D and Zhang X C 2002 Microelectron. J. 33 1043 [2] Fitzgerald A J, Cole B E and Taday P F 2005 J. Pharm. Sci. 94 177 [3] Fitzgerald A J, Wallace V P, Jimenez-Linan M, Bobrow L, Pye R J, Purushotham A D and Arnone D D 2006 Radiology 239 533 [4] Sun Y, Sy M Y, Wang Y X J, Ahuja A T, Zhang Y T and Pickwell Macpherson E 2011 World J. Radiol. 3 55 [5] Chen H, Lee W J, Huang H Y, Chiu C M, Tsai Y F, Tseng T F, Lu J T, Lai W L and Sun C K 2011 Opt. Express 19 19523 [6] Woodward R M, Cole B E, Wallace V P, Pye R J, Arnone D D, Linfield E H and Pepper M 2002 Phys. Med. Biol. 47 3853 [7] Stanley S, Huang S, Wang Y X et al 2010 Phys. Med. Biol. 55 7587 [8] Reid C B, Fitzgerald A, Reese G, Goldin R, Tekkis P, O'Kelly P S, Pickwell-MacPherson E, Gibson A P and Wallace V P 2011 Phys. Med. Biol. 56 4333 [9] Chen L J, Chen H W, Kao T F, Lu J Y and Sun C K 2006 Opt. Lett. 31 308 [10] Chen H W, Li Y T, Pan C L, Kuo J L, Lu J Y, Chen L J and Sun C K 2007 Opt. Lett. 32 1017 [11] Hunsche S, Koch M, Brener I and Nuss M C 1998 Opt. Commun. 150 22 [12] Bethe H A 1944 Phys. Rev. 66 163 [13] Ashworth P C, Pickwell-MacPherson E, Provenzano E, Pinder S E, Purushotham A D, Pepper M and Wallace V P 2009 Opt. Express 17 12444 [14] Png G M, Choi J W, Ng B W, Mickan S P, Abbott D and Zhang X C 2008 Phys. Med. Biol. 53 3501 [15] O'rourke A P, Lazebnik M, Bertram J M, Converse M C, Hagness S C, Webster J G and Mahvi D M 2007 Phys. Med. Biol. 52 4707 [16] Huang S Y, Ashworth P C, Kan K W, Chen Y, Wallace V P, Zhang Y T and Pickwell-MacPherson E 2009 Opt. Express 17 3848
[1]
. [J]. 中国物理快报, 2018, 35(2): 20701-.
[2]
. [J]. 中国物理快报, 2018, 35(1): 13301-.
[3]
. [J]. 中国物理快报, 2016, 33(09): 90701-090701.
[4]
. [J]. 中国物理快报, 2016, 33(04): 44201-044201.
[5]
. [J]. 中国物理快报, 2014, 31(12): 124201-124201.
[6]
LIU Dong, FU Yong-Qi, YANG Le-Chen, ZHANG Bao-Shun, LI Hai-Jun, FU Kai, XIONG Min. Influence of Passivation Layers for Metal Grating-Based Quantum Well Infrared Photodetectors [J]. 中国物理快报, 2012, 29(6): 60701-060701.
[7]
SUN Qi-Zhi;FANG Dong-Fan**;LIU Wei;LIU Zheng-Fen;CHI Yuan;DAI Wen-Feng;HAN Wen-Hui
. Experiments on Broadband EMP Radiation with an Axial Mode Helix Antenna [J]. 中国物理快报, 2011, 28(9): 90702-090702.
[8]
LIN Xu-Ling;ZHANG Jian-Bing;LU Yu;LUO Feng;LU Shan-Liang;YU Tie-Min;DAI Zhi-Min;. High Power THz Undulator Radiation from Linear Accelerator [J]. 中国物理快报, 2010, 27(4): 44101-044101.
[9]
JIU Zhi-Xian;ZUO Du-Luo;MIAO Liang;QI Chun-Chao;CHENG Zu-Hai. An Efficient Pulsed CH3 OH Terahertz Laser Pumped by a TEA CO2 Laser [J]. 中国物理快报, 2010, 27(2): 24211-024211.
[10]
CHEN Hua;WU Xiu-Mei;YANG Wen-Xing. Modulated Terahertz Transmission through Sub-Wavelength Cu Grating by Liquid Water [J]. 中国物理快报, 2010, 27(1): 10701-010701.
[11]
LIN Xu-Ling;ZHANG Jian-Bing;LU YU;LUO Feng;LU Shan-Liang;YU Tie-Min;DAI Zhi-Min;. Characterizing THz Coherent Synchrotron Radiation at Femtosecond Linear Accelerator [J]. 中国物理快报, 2009, 26(12): 124101-124101.
[12]
LIAO Ming-Liang;WEI Yan-Yu;HE Jun;GONG Yu-Bin;WANG Wen-Xiang;Gun-Sik Park. Analysis of a Novel Ka-band Folded Waveguide Amplifier for Traveling-Wave Tubes [J]. 中国物理快报, 2009, 26(11): 114207-114207.
[13]
ZHANG Hui;GUO Peng;CHANG Sheng-Jiang;YUAN Jing-He. Magnetically Tunable Terahertz Switch and Band-Pass Filter [J]. 中国物理快报, 2008, 25(11): 3898-3900.
[14]
HE Shan;QIN Jia-Yin;ZENG Jian-Fen. Theoretical Studies of One-Dimensional Asymmetrical Finite Crystal in Terahertz Laser [J]. 中国物理快报, 2005, 22(1): 36-39.
[15]
YANG Chun-Ling;DAI Jing-Min;HU Yan. Optimum Identifications of Spectral Emissivity and Temperature
for Multi-Wavelength Pyrometry [J]. 中国物理快报, 2003, 20(10): 1685-1688.