Abstract： Calcium is a ubiquitous second messenger. Mitochondria contributes significantly to intracellular Ca2+ dynamics. The experiment of Kaftan et al. [J. Biol. Chem. 275(2000) 25465] demonstrated that inhibiting mitochondrial Ca2+ uptake can reduce the frequency of cytosolic Ca2+ concentration oscillations of gonadotropes. By considering the mitochondrial Ca2+ cycling we develop a three-variable model of intracellular Ca2+oscillations based on the models of Atri et al. [Biophys. J. 65 (1993) 1727] and Falcke et al. [Biophys. J. 77 (1999) 37]. The model reproduces the fact that mitochondrial Ca2+ cycling increases the frequency of cytosolic Ca2+ oscillations, which accords with Kaftan's results. Moreover the model predicts that when the mitochondria overload with Ca2+, the cytosolic Ca2+ oscillations vanish, which may trigger apoptosis.
SHI Xiao-Min;LIU Zeng-Rong. An Intracellular Calcium Oscillations Model Including Mitochondrial Calcium Cycling[J]. 中国物理快报, 2005, 22(12): 3206-3109.
SHI Xiao-Min, LIU Zeng-Rong. An Intracellular Calcium Oscillations Model Including Mitochondrial Calcium Cycling. Chin. Phys. Lett., 2005, 22(12): 3206-3109.
2005, Vol. 22 
