Observation of Hydration--Drying Effect on Clotrimazole--Carbopol System

The possibility to use the polyacrylic acid (carbopol) as polymeric matrix for the clotrimazole is analysed. The hydration--drying effect on the polymeric matrix is observed by Raman spectroscopy. Similar observations are obtained on the clotrimazole included in the polymeric matrix. No modifications of the properties of the clotrimazole and of the polymeric matrix are observed under the repeated action of water.