An Intracellular Calcium Oscillation Model and its Property

Intracellular Ca²⁺ concentration oscillation is one of the typical nonlinear dynamical phenomena in biophysics. According to the experimental facts that when stimulated by different agonists, the cytosolic Ca²⁺ oscillations of hepatocytes show nearly constant amplitude for two different oscillation-form, simple spikes and complex bursts, we build a new 4-variables model based on the two models proposed by Hoefer Biophys J. 77 (1999) 1244 and Kummer et al. Biophys. J. 79 (2000) 1188 Our model can simulate both simple-spike and multi-spike-burst oscillations with amplitude of 0.5-0.7μmol/L in a rather wide range of parameters.