Human Pulmonary Hyperpolarized 129Xe MRI: a Preliminary Study

Funds: Supported by the National Natural Science Foundation of China under Grant Nos 81227902 and 81625011, the National Key Research and Development Program of China under Grant No 2016YFC1304702, and the Key Research Program of Frontier Sciences of CAS (QYZDY-SSW-SLH018).
  • Received Date: September 28, 2017
  • Published Date: April 30, 2018
  • We study the feasibility and safety of human lung hyperpolarized (HP) 129Xe magnetic resonance imaging (MRI). There is no significant change in physiological parameters before and after the examinations of all subjects. Compared with computed tomography, HP 129Xe MRI is sensitive to earlier and smaller ventilation defects. The distribution of the HP 129Xe MRI signal reflects the pulmonary compliance with the gravity gradient. This is the first application of HP 129Xe MRI ventilation imaging in China, and this technology is expected to provide more useful information for clinical practice.
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