Human Pulmonary Hyperpolarized ^129Xe MRI: a Preliminary Study

We study the feasibility and safety of human lung hyperpolarized (HP) ^129Xe magnetic resonance imaging (MRI). There is no significant change in physiological parameters before and after the examinations of all subjects. Compared with computed tomography, HP ^129Xe MRI is sensitive to earlier and smaller ventilation defects. The distribution of the HP ^129Xe MRI signal reflects the pulmonary compliance with the gravity gradient. This is the first application of HP ^129Xe MRI ventilation imaging in China, and this technology is expected to provide more useful information for clinical practice.