Conductance and DNA Translocation Current Blockage of Solid-State Nanopores

The current blockage during DNA molecule translocation through a solid-state nanopore is very important in DNA analysis techniques based on nanopores. We use Poisson–Nernst–Planck descriptions of electrolyte behavior in a nanopore with and without the presence of DNA molecules to simulate the nanopore conductance and current blockage of DNA molecules. Actual experimental parameters, such as pore size, length of nanopores, DNA drift velocity, and the charge issue of nanopores and DNA, are applied to evaluate the precise current blockage amplitude, which is found to agree very well with the experimental results.