Mechanism for Alternating Electric Fields Induced-Effects on Cytosolic Calcium

In this work, from the point of calcium ions in the cytosol, we extend a V_m-Ca²⁺_cyt model to explain the changes of action potential V_m of the plasma membrane and the calcium concentration in the cytosol Ca²⁺_cyt under an alternating electric field in cells. An alternating external electric field may exert an oscillating force to each of the free electrolytes, existing on both sides of the plasma membrane. The mechanism for the alternating electric field induced-effects on V_m and Ca²⁺_cyt is elucidated. The simulation results show a correlation between the changes of Ca²⁺_cyt and the alternating electric field. When the numerical ratio between the intensity E₀(mV/m) and the frequency υ (Hz) of the field was about 1-2, the Ca²⁺_cyt signal is changed dramatically. The bioactive changes of Ca²⁺_{_cyt} appear at low frequency, in the range of 0-100Hz.