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Dynamic Simulation of Single DNA Molecule at the Base Level |
| LEI Xiao-Ling1,2;WANG Xiao-Feng1,2;HU Jun1,3;FANG Hai-Ping1 |
| 1Shanghai Institute of Applied Physics, Chinese Academy of Sciences, PO Box 800-204, Shanghai 201800
2Graduate School of the Chinese Academy of Sciences, Beijing 100039
3Bio-X Life Sciences Research Center, Shanghai Jiao Tong University, Shanghai 200030 |
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| Cite this article: |
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LEI Xiao-Ling, WANG Xiao-Feng, HU Jun et al 2005 Chin. Phys. Lett. 22 1540-1543 |
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Abstract A mesoscopic discrete dsDNA model at the base level is proposed based on the statistical model (Phys. Rev. Lett. 82 (1999) 4560). The numerical simulations reproduce the 65 pN plateau and those on the force vs extension for different supercoiling degrees are favourable with the experimental data. Our model has potential applications on the study of short DNA segments and provides a bridge between the statistical models and atomic modelling.
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| Keywords:
87.14.Gg
87.15.He
36.20.Ey
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Published: 01 June 2005
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