| CONDENSED MATTER: STRUCTURE, MECHANICAL AND THERMAL PROPERTIES |
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A Method to Design Synthetic Cell-Cycle Networks |
| MIAO Ke-Ke |
| National Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093 |
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| Cite this article: |
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MIAO Ke-Ke 2009 Chin. Phys. Lett. 26 076401 |
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Abstract The interactions among proteins, DNA and RNA in an organism form elaborate cell-cycle networks which govern cell growth and proliferation. Understanding the common structure of cell-cycle networks will be of great benefit to science research. Here, inspired by the importance of the cell-cycle regulatory network of yeast which has been studied intensively, we focus on small networks with 11 nodes, equivalent to that of the cell-cycle regulatory network used by Li et al. [Proc. Natl. Acad. Sci. USA 101(2004)4781] Using a Boolean model, we study the correlation between structure and function, and a possible common structure. It is found that cascade-like networks with a great number of interactions between nodes are stable. Based on these findings, we are able to construct synthetic networks that have the same functions as the cell-cycle regulatory network.
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| Keywords:
64.60.Aq
89.75.-k
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Received: 16 March 2009
Published: 02 July 2009
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