Effects of pH on Oxaliplatin-Induced Condensation of Single DNA Molecules
ZHANG Hong-Yan, JI Chao, LIU Yu-Ru, LI Wei, LI Hui, DOU Shuo-Xing, WANG Wei-Chi, ZHANG Ling-Yun, XIE Ping, WANG Peng-Ye**
Key Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190
Abstract：By using magnetic tweezers, atomic force microscope and mass spectrometry, we study the effects of pH on oxaliplatin-induced DNA condensation, the DNA persistence length, the amounts of micro-loops and of oxaliplatin bound to DNA. It is found that the DNA condensation degree, the amounts of micro-loops and of oxaliplatin bound to DNA increase with the decrease in the pH value while the DNA persistence length has an opposite behavior. The observed effects may be related to the drug resistance of cancer cells.
(Single molecule manipulation of proteins and other biological molecules)
引用本文:
. [J]. 中国物理快报, 2014, 31(2): 28701-028701.
ZHANG Hong-Yan, JI Chao, LIU Yu-Ru, LI Wei, LI Hui, DOU Shuo-Xing, WANG Wei-Chi, ZHANG Ling-Yun, XIE Ping, WANG Peng-Ye. Effects of pH on Oxaliplatin-Induced Condensation of Single DNA Molecules. Chin. Phys. Lett., 2014, 31(2): 28701-028701.
2014, Vol. 31 
