Preparation and Characterization of Bimodal Magnetofluorescent Nanoprobes for Biomedical Application
LEI Jie-Mei1, XU Xiao-Liang1**, LIU Ling1, YIN Nai-Qiang1, ZHU Li-Xin2**
1Department of Physics, University of Science and Technology of China, Hefei 230026 2Center Laboratory, First Affiliated Hospital, Anhui Medical University, Hefei 230022
Abstract：Magnetic-fluorescent bifunctional Fe3O4/SiO2-CdTeS nanocomposites are synthesized. Fe3O4 superparamagnetic nanoparticles are firstly prepared through the thermal decomposition of Fe oleate precursors and coated with a mesoporous silica shell using the St?ber method, and the silica surface is then modified with positively charged amino groups by adding 3-aminopropyltrimethoxysilane. Finally, negatively charged CdTeS quantum dots are linked and assembled onto the positively charged surface of Fe3O4/SiO2 through electrostatic interactions. X-ray diffraction, transmission electron microscopy, photoluminescence spectroscopy, and magnetometry are applied to characterize the nanocomposites. The results show that the bifunctional nanocomposites combine the optical properties of near-infrared CdTeS quantum dots with the superparamagnetic properties of Fe3O4 perfectly, expressing the potential application as a biocompatible magnetofuorescent nanoprobe for in vivo labelling.
2012, Vol. 29 
