Coupling Effect of Ion Channel Clusters on Calcium Signalling
TANG Jun1,2, JIA Ya1, YI Ming1, MA Jun1, YU Guang1
1Department of Physics and Institute of Biophysics, Huazhong Normal University, Wuhan 4300792College of Science, China University of Mining and technology, Xuzhou 221008
Coupling Effect of Ion Channel Clusters on Calcium Signalling
TANG Jun1,2;JIA Ya1;YI Ming1;MA Jun1;YU Guang1
1Department of Physics and Institute of Biophysics, Huazhong Normal University, Wuhan 4300792College of Science, China University of Mining and technology, Xuzhou 221008
摘要Based on a modified intracellular Ca2+ model involving diffusive coupling of two calcium ion channel clusters, the effects of coupling on calcium signalling are numerically investigated. The simulation results indicate that the diffusive coupling of clusters together with internal noise determine the calcium dynamics of single cluster, and for either homogeneous or heterogeneous coupled clusters, the synchronization of clusters, which is important to calcium signalling, is enhanced by the coupling effect.
Abstract：Based on a modified intracellular Ca2+ model involving diffusive coupling of two calcium ion channel clusters, the effects of coupling on calcium signalling are numerically investigated. The simulation results indicate that the diffusive coupling of clusters together with internal noise determine the calcium dynamics of single cluster, and for either homogeneous or heterogeneous coupled clusters, the synchronization of clusters, which is important to calcium signalling, is enhanced by the coupling effect.
(Fluctuation phenomena, random processes, noise, and Brownian motion)
引用本文:
TANG Jun;JIA Ya;YI Ming;MA Jun;YU Guang. Coupling Effect of Ion Channel Clusters on Calcium Signalling[J]. 中国物理快报, 2008, 25(3): 1149-1152.
TANG Jun, JIA Ya, YI Ming, MA Jun, YU Guang. Coupling Effect of Ion Channel Clusters on Calcium Signalling. Chin. Phys. Lett., 2008, 25(3): 1149-1152.
[1] Cornell-Bell A H et al 1990 Science 47 470 [2]Golovina V A and Blaustein M P 1997 Science 2751643 [3]Koninck P D and Schulman H 1998 Science 279 227 [4]Dolmetsch R E et al 1998 Nature 392 933 [5]Allen G J 2000 Science 289 2338 [6]Bootman M et al 1997 J. Physiol. 499307 [7]Callamaras N et al 1998 J. Physiol. 509 81 [8]Lipp P and Niggli E 1998 J. Physiol. 508 801 [9]Kepseu W D and woafo P 2006 Phys Rev. E. 73041912 [10]Li Q S and He H Y 2005 J. Chem. Phys. 123214905 [11]Zhou T S et al 2005 Phys. Rev. Lett. 95 178103 [12]Wang M S et al 2006 Chin. Phys. Lett. 15 2553 Li Q S and Li Y P 2006 Phys. Rev. E. 69 031109 [13]Wang M S et al 2006 Chin. Phys. Lett. 23 508 Hou Z H 2006 Phys. Rev. E. 74 031901 Li Q S and Wang Y 2007 Biophys. Chem. 129 23 [14]Shuai J W and Jung P 2003 New J. phys. 5 132 [15]Li Y X and Rinzel J 1994 J. Theor. Biol. 166461 [16]Diambra L and Guisoni N 2005 Cell Calcium 37321 [17]De Young G W and Keizer J 1992 Proc. Natl. Acad.Sci. USA 89 9895 [18]Shuai J W and Jung P 2002 Phys. Rev. Lett. 8868102 [19]Mazzag B et al 2005 J. Theor. Biol. 235 121 [20]Falcke M et al 2000 Phys. Rev. E. 62 2636 [21]Shuai J W and Jung P 2002 Biophys. J. 83 87
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