Suppression of Spiral Waves by Voltage Clamp Techniques in a Conductance-Based Cardiac Tissue Model
YU Lian-Chun1, MA Jun2, ZHANG Guo-Yong1, CHEN Yong 1,3
1Institute of Theoretical Physics, Lanzhou University, Lanzhou 7300002Department of Physics, Lanzhou University of Technology,Lanzhou 7300503Key Laboratory for Magnetism and Magnetic materials of the Ministry of Education, Lanzhou University, Lanzhou 730000
Suppression of Spiral Waves by Voltage Clamp Techniques in a Conductance-Based Cardiac Tissue Model
YU Lian-Chun1, MA Jun2, ZHANG Guo-Yong1, CHEN Yong 1,3
1Institute of Theoretical Physics, Lanzhou University, Lanzhou 7300002Department of Physics, Lanzhou University of Technology,Lanzhou 7300503Key Laboratory for Magnetism and Magnetic materials of the Ministry of Education, Lanzhou University, Lanzhou 730000
摘要A new control method is proposed to control the spatio-temporal dynamics in excitable media, which is described by the Morris–Lecar cells model. It is confirmed that successful suppression of spiral waves can be obtained by spatially clamping the membrane voltage of the excitable cells. The low voltage clamping induces breakup of spiral waves and the fragments are soon absorbed by low voltage obstacles, whereas the high voltage clamping generates travel waves that annihilate spiral waves through collision with them. However, each method has its shortcomings. Furthermore, a two-step method that combines both low and high voltage clamp techniques is then presented as a possible way of out this predicament.
Abstract：A new control method is proposed to control the spatio-temporal dynamics in excitable media, which is described by the Morris–Lecar cells model. It is confirmed that successful suppression of spiral waves can be obtained by spatially clamping the membrane voltage of the excitable cells. The low voltage clamping induces breakup of spiral waves and the fragments are soon absorbed by low voltage obstacles, whereas the high voltage clamping generates travel waves that annihilate spiral waves through collision with them. However, each method has its shortcomings. Furthermore, a two-step method that combines both low and high voltage clamp techniques is then presented as a possible way of out this predicament.
YU Lian-Chun;MA Jun;ZHANG Guo-Yong;CHEN Yong;. Suppression of Spiral Waves by Voltage Clamp Techniques in a Conductance-Based Cardiac Tissue Model[J]. 中国物理快报, 2008, 25(7): 2706-2709.
YU Lian-Chun, MA Jun, ZHANG Guo-Yong, CHEN Yong,. Suppression of Spiral Waves by Voltage Clamp Techniques in a Conductance-Based Cardiac Tissue Model. Chin. Phys. Lett., 2008, 25(7): 2706-2709.
2008, Vol. 25 
