Dynamic Simulation of Single DNA Molecule at the Base Level
LEI Xiao-Ling1,2, WANG Xiao-Feng1,2, HU Jun1,3, FANG Hai-Ping1
1Shanghai Institute of Applied Physics, Chinese Academy of Sciences, PO Box 800-204, Shanghai 201800
2Graduate School of the Chinese Academy of Sciences, Beijing 100039
3Bio-X Life Sciences Research Center, Shanghai Jiao Tong University, Shanghai 200030
Dynamic Simulation of Single DNA Molecule at the Base Level
LEI Xiao-Ling1,2;WANG Xiao-Feng1,2;HU Jun1,3;FANG Hai-Ping1
1Shanghai Institute of Applied Physics, Chinese Academy of Sciences, PO Box 800-204, Shanghai 201800
2Graduate School of the Chinese Academy of Sciences, Beijing 100039
3Bio-X Life Sciences Research Center, Shanghai Jiao Tong University, Shanghai 200030
Abstract： A mesoscopic discrete dsDNA model at the base level is proposed based on the statistical model (Phys. Rev. Lett. 82 (1999) 4560). The numerical simulations reproduce the 65 pN plateau and those on the force vs extension for different supercoiling degrees are favourable with the experimental data. Our model has potential applications on the study of short DNA segments and provides a bridge between the statistical models and atomic modelling.
LEI Xiao-Ling;WANG Xiao-Feng;HU Jun;FANG Hai-Ping. Dynamic Simulation of Single DNA Molecule at the Base Level[J]. 中国物理快报, 2005, 22(6): 1540-1543.
LEI Xiao-Ling, WANG Xiao-Feng, HU Jun, FANG Hai-Ping. Dynamic Simulation of Single DNA Molecule at the Base Level. Chin. Phys. Lett., 2005, 22(6): 1540-1543.
2005, Vol. 22 
