Local Magnetic Nanoparticle Delivery in Microvasculature
GUO Ping1,2, LI Xin-Xia2, XIONG Ping1, HE Ji-Shan1
1School of Info-Physics and Geomatics Engineering, Central South University, Changsha 4100832Department of Nuclear Physics, University of South China, Hengyang 421001
Local Magnetic Nanoparticle Delivery in Microvasculature
GUO Ping1,2, LI Xin-Xia2, XIONG Ping1, HE Ji-Shan1
1School of Info-Physics and Geomatics Engineering, Central South University, Changsha 4100832Department of Nuclear Physics, University of South China, Hengyang 421001
摘要The transport and capture of therapeutic magnetic nanoparticles in human microvasculature is studied numerically. The nanoparticles are injected into a vascular system upstream from malignant tissue, and are captured at the tumour site with the aid of a local applied magnetic field positioned outside the body. Taking into account the dominant magnetic and fluidic forces on the particles, our study shows that the nanoparticles can be directed to and concentrated at the desired zone that is within a few centimetres from the surface of the body. In addition, influence of the particles size, average blood flow velocity and the diameter of the blood vessel on the captured efficiency are parametrically analysed.
Abstract：The transport and capture of therapeutic magnetic nanoparticles in human microvasculature is studied numerically. The nanoparticles are injected into a vascular system upstream from malignant tissue, and are captured at the tumour site with the aid of a local applied magnetic field positioned outside the body. Taking into account the dominant magnetic and fluidic forces on the particles, our study shows that the nanoparticles can be directed to and concentrated at the desired zone that is within a few centimetres from the surface of the body. In addition, influence of the particles size, average blood flow velocity and the diameter of the blood vessel on the captured efficiency are parametrically analysed.
GUO Ping;LI Xin-Xia;XIONG Ping;HE Ji-Shan. Local Magnetic Nanoparticle Delivery in Microvasculature[J]. 中国物理快报, 2009, 26(1): 18703-018703.
GUO Ping, LI Xin-Xia, XIONG Ping, HE Ji-Shan. Local Magnetic Nanoparticle Delivery in Microvasculature. Chin. Phys. Lett., 2009, 26(1): 18703-018703.
[1] Christoph A, Wolfgang A, Roswitha J K, Fritz G P, Peter H,Christian B, Wolfgang E, Stefan W and Andreas S L 2000 CancerRes. 60 6641 [2] Shelton D C, Samuel A W and Gregory M L 2007 Curr.Opinion Biotech. 18 1 [3] Andreas S L, Christoph A and Christian B 2001 J Surg.Res. 95 200 [4] Widder K J, Morris R M, Poore G H and Senyei A E 1983 Eur. J. Cancer Clin. Oncol. 19 135 [5] Li J P, Wu C H, Gao F, Zhang R Y, Lu Gang, Fu D G, Ch B Aand Wang X M 2006 Bioorg. Med. Chem. L 16 4808 [6] Zhang L Y, Dou Y H, Zhang L and Gu H C 2007 Chin.Phys. Lett. 24 3253 [7] Ritter J A, Ebner A D, Daniel K D and Stewart K L 2004 J. Magn. Magn. Mater. 280 184 [8] Pulfer S K and Gallo J M 1999 J. Drug Target 6215 [9] Xiong P, Guo P, Xiang D and He J S 2006 Act Phys.Sin. 55 4383 (in Chinese) [10] Pu S L, Chen X F, Di Z Y, Geng T and Xia Y X 2007 Chin. Phys. Lett. 24 483 [11] Chen H T, Ebne A D, Kaminski M D, Rosengart A J andRitter J A 2004 J. Magn. Magn. Mater. 280 184 [12] Misael O A, Armin D E and Ritter J A 2006 J.Magn. Magn. Mater. 310 131 [13] Ovidiu R and Norval J C S 2005 J. Magn. Magn.Mater. 293 639 [14] Purlani E P and Ng K C 2006 Phys. Rev. E 73061919 [15] Zhang R Y, Wang X M, Wu C H, Song M, Li J Y, Lv G, ZhouJ, Chen C, Dai Y Y, Gao F, Fu D G, LI X M, Guan Z Q and Chen B A2006 Nanotechnology 17 3622 [16] Fletcher D 1991 IEEE Trans. Magn. 27 3655 [17] Purlani E P 2001 Permanent Magnet andElectromechanical Devices: Materials, Analysis and Applications(New York: Academic) [18] Pries A P, Secomb T W and Gaehtgens P 1996 Cardiovasc. Res. 32 654
2009, Vol. 26 
