摘要Dissolved cardiac myocytes can couple together and generate synchronous beatings in culture. We observed a synchronized early after-depolarization(EAD)-like rhythm in cultured cardiac myocytes and reproduced the experimental observation in a network mathematical model whose dynamics are close to a Hopf bifurcation. The mechanism for this EAD-like rhythm is attributed to noised-induced stochastic alternatings between the focus and the limit cycle. These results provide novel understandings for pathological heart rhythms like the early immature beatings.
Abstract：Dissolved cardiac myocytes can couple together and generate synchronous beatings in culture. We observed a synchronized early after-depolarization(EAD)-like rhythm in cultured cardiac myocytes and reproduced the experimental observation in a network mathematical model whose dynamics are close to a Hopf bifurcation. The mechanism for this EAD-like rhythm is attributed to noised-induced stochastic alternatings between the focus and the limit cycle. These results provide novel understandings for pathological heart rhythms like the early immature beatings.
[1] Boccaletti S, Kurths J, Osopv G, Valladares D L and Zhou CS 2002 Phys. Rep. 366 1 [2] Steinmetz P N, Roy A, Fitzgerald P J, Hsiao S S, Johnson KO and Niebur E 2000 Nature 404 187 [3] Wang Q Y and Lu Q S 2005 Chin. Phys. Lett. 221329 [4] Glass L 2001 Nature 410 277 [5] Sun X J and Lu Q S 2009 Chin. Phys. Lett. 26060507 [6] Li M S, Lu Q S, Duan L X and Wang Q Y 2008 Chin.Phys. Lett. 25 2806 [7] Jalife J 1984 J. Physiol. 356 221 [8] Burashnikov A and Antzelevitch C 2003 Circulation 107 2355 [9] Levine J H, Spear J F, Guarnieri T, Weisfeldt M L,DeLangen C D J, Becker L C and Moore E N 1985 Circulation 72 1092 [10] Volders P G, Vos M A, Szabo B, Sipido K R, de Groot S H,Gorgels A P, Wellens H J and Lazzara R 2000 Cardiovasc. Res. 46 376 [11] Bub G, Glass L, Publicover N G and Shrier A 1998 Proc. Natl. Acad. Sci. U.S.A. 95 10283 [12] Ponard J G, Kondratyev A and Kucera J P 2007 Biophys. J. 92 3734 [13] Cohen N, Soen Y and Braun E 1998 Physica A 249 600 [14] Kimura H, Oyamada Y, Ohshika H, Mori M and Oyamada M 1995 Exp. Cell. Res. 220 348 [15] Soen. Y, Cohen N, Lipson D and Braun E 1999 Phys.Rev. Lett. 82 3556 [16] Ryoichi A and Masahiko H 2005 Biophys. Chem. 116 33 [17] Tsumoto K, Kitajima H, Yoshinaga T, Aihara K and KawakamiH 2006 Neurocomputing 69 293 [18] Yu L C, MA J, Zhang G Y and Chen Y 2008 Chin. Phys.Lett. 25 2706 [19] Li Y Y, Zhang H M, Wei C L, Yang M H, Gu H G and Ren W2009 Chin. Phys. Lett. 26 030504 [20] Kanakov O I, Osipov G V, Chan C K and Kurths J 2007 Chaos 17 015111 [21] Bub G, Shrier A and Glass L 2005 Phys. Rev. Lett. 94 028105 [22] Cai D, Lai Y C and Winslow R L 1993 Phys. Rev.Lett. 71 2501 [23] Winslow R L, Cai D, Varghese A and Lai Y 1995 Chaos,Soliton Fractals 5 491 [24] Cai D, Winslow R L and Noble D 1994 IEEE Trans.Biomed. Eng. 41 217
2009, Vol. 26 
