Cytoplasmic Ca2+ Dynamics under the Interplay between the Different IP3R Gating Models and the Plasma Membrane Ca2+ Influx
CHEN Xiao-Fang, LI Cong-Xin, WANG Peng-Ye, WANG Wei-Chi
Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190
Cytoplasmic Ca2+ Dynamics under the Interplay between the Different IP3R Gating Models and the Plasma Membrane Ca2+ Influx
CHEN Xiao-Fang, LI Cong-Xin, WANG Peng-Ye, WANG Wei-Chi
Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190
摘要The cytoplasmic Ca2+ oscillations are investigated under the effect of CRAC channels in non-excitable cells (especially in T cells). The oscillatory Ca2+ signals can be modulated as the amplitude-, frequency- and mixed amplitude-frequency modulation modes dependent on the different IP3R gating models. Bifurcation analyses show that Ca2+ signals in the single positive feedback loop model is a mixed modulation mode. In contrast, Ca2+ signals in the Mak-McBride-Foskett model demonstrates approximately the frequency modulation mode only with slight amplitude shifts.
Abstract：The cytoplasmic Ca2+ oscillations are investigated under the effect of CRAC channels in non-excitable cells (especially in T cells). The oscillatory Ca2+ signals can be modulated as the amplitude-, frequency- and mixed amplitude-frequency modulation modes dependent on the different IP3R gating models. Bifurcation analyses show that Ca2+ signals in the single positive feedback loop model is a mixed modulation mode. In contrast, Ca2+ signals in the Mak-McBride-Foskett model demonstrates approximately the frequency modulation mode only with slight amplitude shifts.
CHEN Xiao-Fang;LI Cong-Xin;WANG Peng-Ye;WANG Wei-Chi. Cytoplasmic Ca2+ Dynamics under the Interplay between the Different IP3R Gating Models and the Plasma Membrane Ca2+ Influx[J]. 中国物理快报, 2010, 27(1): 10504-010504.
CHEN Xiao-Fang, LI Cong-Xin, WANG Peng-Ye, WANG Wei-Chi. Cytoplasmic Ca2+ Dynamics under the Interplay between the Different IP3R Gating Models and the Plasma Membrane Ca2+ Influx. Chin. Phys. Lett., 2010, 27(1): 10504-010504.
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2010, Vol. 27 
