Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells
LI Cong-Xin, CHEN Xiao-Fang, WANG Peng-Ye, WANG Wei-Chi
Laboratory of Soft Matter Physics, Beijing National Laboratory for CondensedMatter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190
Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells
LI Cong-Xin, CHEN Xiao-Fang, WANG Peng-Ye, WANG Wei-Chi
Laboratory of Soft Matter Physics, Beijing National Laboratory for CondensedMatter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190
摘要A reaction-diffusion model is built to investigate the temporal and spatial patterns of cytoplasmic Ca2+ dynamics under the effects of Ca2+-release activated Ca2+ (CRAC) channels in T cells. Simulation results show a strong dependence of the modulation mode of Ca2+ oscillation and dynamic patterns of Ca2+ wave on the influx rate through the CRAC channel (ksoc). When ksoc is small, cytoplasmic Ca2+ is modulated as a frequency-modulation (FM) signal, whereas it shows an amplitude modulation (AM) mode after ksoc passes through a critical value. The heterogeneity in spatial Ca2+ distribution is mostly arising from the influx through CRAC channels in both FM and AM modes. During each Ca2+ spike, a more sustained cytoplasmic Ca2+ gradient is maintained in the AM mode rather than in the FM mode.
Abstract：A reaction-diffusion model is built to investigate the temporal and spatial patterns of cytoplasmic Ca2+ dynamics under the effects of Ca2+-release activated Ca2+ (CRAC) channels in T cells. Simulation results show a strong dependence of the modulation mode of Ca2+ oscillation and dynamic patterns of Ca2+ wave on the influx rate through the CRAC channel (ksoc). When ksoc is small, cytoplasmic Ca2+ is modulated as a frequency-modulation (FM) signal, whereas it shows an amplitude modulation (AM) mode after ksoc passes through a critical value. The heterogeneity in spatial Ca2+ distribution is mostly arising from the influx through CRAC channels in both FM and AM modes. During each Ca2+ spike, a more sustained cytoplasmic Ca2+ gradient is maintained in the AM mode rather than in the FM mode.
LI Cong-Xin;CHEN Xiao-Fang;WANG Peng-Ye;WANG Wei-Chi. Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells[J]. 中国物理快报, 2010, 27(2): 28701-028701.
LI Cong-Xin, CHEN Xiao-Fang, WANG Peng-Ye, WANG Wei-Chi. Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells. Chin. Phys. Lett., 2010, 27(2): 28701-028701.
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2010, Vol. 27 
