Numerical Simulations of Calcium Ions Spiral Wave in Single Cardiac Myocyte
BAI Yong-Qiang1, ZHU Xing2,3
1College of Electronic Science, Daqing Petroleum Institute,Daqing 1633182School of Physics, State Key Laboratory for Artificial Microstructureand Mesoscopic Physics, Peking University, Beijing 1008713National Center for Nanoscience and Technology, Beijing 100080
Numerical Simulations of Calcium Ions Spiral Wave in Single Cardiac Myocyte
BAI Yong-Qiang1, ZHU Xing2,3
1College of Electronic Science, Daqing Petroleum Institute,Daqing 1633182School of Physics, State Key Laboratory for Artificial Microstructureand Mesoscopic Physics, Peking University, Beijing 1008713National Center for Nanoscience and Technology, Beijing 100080
The calcium ions (Ca2+) spark is an elementary Ca2+ release event in cardiac myocytes. It is believed to buildup cell-wide Ca2+ signals, such as Ca2+ transient and Ca2+ wave, through a Ca2+-induced Ca2+ release (CICR) mechanism. Here the excitability of the Ca2+ wave in a single cardiac myocyte is simulated by employing the fire-diffuse-fire model. By modulating the dynamic parameters of Ca2+ release and re-uptake channels, we find three Ca2+ signaling states in a single cardiac myocyte: no wave, plane wave, and spiral wave. The period of a spiral wave is variable in the different regimes. This study indicates that the spiral wave or the excitability of the system can be controlled through micro-modulation in a living excitable medium.
The calcium ions (Ca2+) spark is an elementary Ca2+ release event in cardiac myocytes. It is believed to buildup cell-wide Ca2+ signals, such as Ca2+ transient and Ca2+ wave, through a Ca2+-induced Ca2+ release (CICR) mechanism. Here the excitability of the Ca2+ wave in a single cardiac myocyte is simulated by employing the fire-diffuse-fire model. By modulating the dynamic parameters of Ca2+ release and re-uptake channels, we find three Ca2+ signaling states in a single cardiac myocyte: no wave, plane wave, and spiral wave. The period of a spiral wave is variable in the different regimes. This study indicates that the spiral wave or the excitability of the system can be controlled through micro-modulation in a living excitable medium.
BAI Yong-Qiang;ZHU Xing;. Numerical Simulations of Calcium Ions Spiral Wave in Single Cardiac Myocyte[J]. 中国物理快报, 2010, 27(4): 48201-048201.
BAI Yong-Qiang, ZHU Xing,. Numerical Simulations of Calcium Ions Spiral Wave in Single Cardiac Myocyte. Chin. Phys. Lett., 2010, 27(4): 48201-048201.
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2010, Vol. 27 
