Effects of Time-Delay on Intracellular Ca2+ Concentration Oscillations
YING Yang-Jun1,2, HUANG Zu-Qia1
1Institute of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875
2Institute of Applied Physics and Computational Mathematics, P. O. Box 8009, Beijing 100088
Effects of Time-Delay on Intracellular Ca2+ Concentration Oscillations
YING Yang-Jun1,2; HUANG Zu-Qia1
1Institute of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875
2Institute of Applied Physics and Computational Mathematics, P. O. Box 8009, Beijing 100088
Abstract： Based on SS-model [Somogyi R and Stucki J W J. Biol. Chem. 266 (1991) 11068] for the generation of intracellular Ca2+ concentration oscillations, we consider a time-delay for the binding kinetics of the Ca2+ channel and find a significant phenomenon that the oscillation takes two quite different modes when a parameter of the system across a threshold. One is a quick oscillation mode and the other is a slow oscillation mode. They are different from each other on oscillation frequencies for more than ten times. The change of oscillation form with parameters and its critical behaviour are illustrated by numerical simulation results.
2001, Vol. 18 
