Acoustic Nonlinear Behaviour of Microbubble Contrast Agent
YU Jin-Fei1, LU Rong-Rong1, GONG Xiu-Fen1, William T. Shi2
1State Key Laboratory of Modern Acoustics Institute of Acoustics, Nanjing University, Nanjing 210093
2Department of Radiology and Jefferson Ultrasound Research and Education Institute, Thomas Jefferson University, PA 19107, USA
Acoustic Nonlinear Behaviour of Microbubble Contrast Agent
YU Jin-Fei1;LU Rong-Rong1;GONG Xiu-Fen1;William T. Shi2
1State Key Laboratory of Modern Acoustics Institute of Acoustics, Nanjing University, Nanjing 210093
2Department of Radiology and Jefferson Ultrasound Research and Education Institute, Thomas Jefferson University, PA 19107, USA
Abstract： We have investigated the nonlinear characteristics of a microbubble contrast agent SonazoidR (Nycomed, Norway), including the second, third, 1/2-order, 3/2-order and 5/2-order harmonics. We have measured the 1/2-order subharmonic response to different transmit sound pressure. It is found that subharmonic signals can not be generated until the acoustic pressure reached a certain value, which is the most difference subharmonic from high harmonics. This result is favorable for the further study of the subharmonic in the bubbly liquid. The 3/2-order ultraharmoic response to acoustic pressure was also measured.
2002, Vol. 19 
