Real-Time Measurements and Modelling on Dynamic Behaviour of SonoVue Bubbles Based on Light Scattering Technology
TU Juan1,2, GUAN J. F.2, MATULA T. J.2, Crum L. A.2, WEI Rongjue1
1Key Laboratory of Modern Acoustics (Ministry of Education), Nanjing University, Nanjing 2100932Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA, 98105, USA
Real-Time Measurements and Modelling on Dynamic Behaviour of SonoVue Bubbles Based on Light Scattering Technology
TU Juan1,2;GUAN J. F.2;MATULA T. J.2;Crum L. A.2;WEI Rongjue1
1Key Laboratory of Modern Acoustics (Ministry of Education), Nanjing University, Nanjing 2100932Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA, 98105, USA
摘要The dynamic behaviour of SonoVue microbubbles, a new generation ultrasound contrast agent, is investigated in real time with light scattering method. Highly diluted SonoVue microbubbles are injected into a diluted gel made of xanthan gum and water. The responses of individual SonoVue bubbles to driven ultrasound pulses are measured. Both linear and nonlinear bubble oscillations are observed and the results suggest that SonoVue microbubbles can generate strong nonlinear responses. By fitting the experimental data of individual bubble responses with Sarkar's model, the shell coating parameter of the bubbles and dilatational viscosity is estimated to be 7.0 nm·s·Pa.
Abstract：The dynamic behaviour of SonoVue microbubbles, a new generation ultrasound contrast agent, is investigated in real time with light scattering method. Highly diluted SonoVue microbubbles are injected into a diluted gel made of xanthan gum and water. The responses of individual SonoVue bubbles to driven ultrasound pulses are measured. Both linear and nonlinear bubble oscillations are observed and the results suggest that SonoVue microbubbles can generate strong nonlinear responses. By fitting the experimental data of individual bubble responses with Sarkar's model, the shell coating parameter of the bubbles and dilatational viscosity is estimated to be 7.0 nm·s·Pa.
TU Juan;GUAN J. F.;MATULA T. J.;Crum L. A.;WEI Rongjue. Real-Time Measurements and Modelling on Dynamic Behaviour of SonoVue Bubbles Based on Light Scattering Technology[J]. 中国物理快报, 2008, 25(1): 172-175.
TU Juan, GUAN J. F., MATULA T. J., Crum L. A., WEI Rongjue. Real-Time Measurements and Modelling on Dynamic Behaviour of SonoVue Bubbles Based on Light Scattering Technology. Chin. Phys. Lett., 2008, 25(1): 172-175.
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2008, Vol. 25 
