Inverse Optimizing Method of Bio-Temperature-Field Reconstruction in rf-Capacitive Hyperthermia
WAN Bai-Kun1, ZHU Xin1, CHENG Xiao-Man2, LIN Shi-Yin3
1Department of Biomedical Engineering and Scientific Instrument, Tianjin University, Tianjin 300072
2Department of Optoelectronic Information and Electronic Engineering, Tianjin Institute of Technology, Tianjin 300191
3Division of Radio-Physics, Tianjin Cancer Institute and Hospital, Tianjin 300060
Inverse Optimizing Method of Bio-Temperature-Field Reconstruction in rf-Capacitive Hyperthermia
WAN Bai-Kun1;ZHU Xin1;CHENG Xiao-Man2;LIN Shi-Yin3
1Department of Biomedical Engineering and Scientific Instrument, Tianjin University, Tianjin 300072
2Department of Optoelectronic Information and Electronic Engineering, Tianjin Institute of Technology, Tianjin 300191
3Division of Radio-Physics, Tianjin Cancer Institute and Hospital, Tianjin 300060
Abstract： We propose an inverse optimizing method, used in rf-capacitive hyperthermia to obtain a certain target tumor temperature and to avoid the over-heating of normal tissues. Based on the finite-element-method solutions of the Laplace electric potential equation and Penne's bio-heat transfer equation, the heating conditions are modified by the genetic algorithms recursively to minimize the objective function for searching an optimum physical configuration. With a simplified human tissue model extracted from an x-ray computed tomography slice which has deep- and shallow-seated tumors, satisfied simulation results are obtained both on bi-plate and three-plate systems, e.g., the tumor temperature is higher than 43°C and the temperature of normal tissues is lower than 39°C. It is suggested that the proposed algorithm is suitable for both shallow and deep seated cancer oncology.
2003, Vol. 20 
