Increase in the Transition Enthalpy of Fibrinogen upon Adsorption onto Hydroxyapatite
CHEN Yong-li, MAO Hai-bin, ZHANG Xiu-fang, GONG Yan-dao, ZHAO Nan-ming
Department of Biological Science and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084
Increase in the Transition Enthalpy of Fibrinogen upon Adsorption onto Hydroxyapatite
Department of Biological Science and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084
Abstract： The increase of the protein transition enthalpy upon adsorption onto biomedical material surfaces was observed by measuring the differential scanning calorimetry (DSC) traces of bovine fibrinogen adsorbed onto a hydroxyapatite surface. The mechanism causing the transition enthalpy increase upon adsorption Was clarified by using DSC measurements of bovine fibrinogen for different ionic strength and sodium dodecyl sulfate concentrations. The results suggest that the increased fibrinogen transition enthalpy may be attributed to the electrostatic interactions between the carboxyl of the D domains and the calcium loci of hydroxyapatite, which may result in a more compact protein structure.
CHEN Yong-li;MAO Hai-bin;ZHANG Xiu-fang;GONG Yan-dao;ZHAO Nan-ming
. Increase in the Transition Enthalpy of Fibrinogen upon Adsorption onto Hydroxyapatite[J]. 中国物理快报, 1999, 16(6): 431-433.
CHEN Yong-li, MAO Hai-bin, ZHANG Xiu-fang, GONG Yan-dao, ZHAO Nan-ming
. Increase in the Transition Enthalpy of Fibrinogen upon Adsorption onto Hydroxyapatite. Chin. Phys. Lett., 1999, 16(6): 431-433.
1999, Vol. 16 
