Quantum Approach to Fast Protein-Folding Time
Li-Hua Lu1 , You-Quan Li1,2**
1 Zhejiang Province Key Laboratory of Quantum Technology & Device, and Department of Physics, Zhejiang University, Hangzhou 3100272 Collaborative Innovation Center of Advanced Microstructure, Nanjing University, Nanjing 210008
Abstract ：In the traditional random-conformational-search model, various hypotheses with a series of meta-stable intermediate states were proposed to resolve the Levinthal paradox in protein-folding time. Here we introduce a quantum strategy to formulate protein folding as a quantum walk on a definite graph, which provides us a general framework without making hypotheses. Evaluating it by the mean of first passage time, we find that the folding time via our quantum approach is much shorter than the one obtained via classical random walks. This idea is expected to evoke more insights for future studies.
收稿日期: 2019-07-26
出版日期: 2019-07-30
:
03.67.Ac
(Quantum algorithms, protocols, and simulations)
87.15.hm
(Folding dynamics)
05.40.Fb
(Random walks and Levy flights)
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2019, Vol. 36 
