| CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
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Photo-Crosslinking Induced Geometric Restriction Controls the Self-Assembly of Diphenylalanine Based Peptides |
| TIE Zuo-Xiu, QIN Meng**, ZOU Da-Wei, CAO Yi**, WANG Wei
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National Laboratory of Solid State Microstructure and Department of Physics, Nanjing University, Nanjing 210093
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TIE Zuo-Xiu, QIN Meng, ZOU Da-Wei et al 2011 Chin. Phys. Lett. 28 028702 |
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Abstract The diphenylalanine (FF) motif has been widely used in the design of peptides that are capable of forming various ordered structures, such as nanotubes, nanospheres and hydrogels. In these assemblies, FF based peptides adopt an antiparallel structure and are stabilized by π−π stacking among the phenyl groups. Here we show that assembly of FF-based peptides can be controlled by their geometric restrictions. Using tripeptide FFY (L-Phe-L-Phe-L-Tyr) as an example, we demonstrate that photo-crosslinking of C-terminal tyrosine can impose a geometric restriction to the formation of an antiparallel structure, leading to a structural change of the assemblies from nanosphere to amorphous. This finding is confirmed using far-UV circular dichroism, Fourier transform infrared spectroscopy and atomic force microscopy. Based on such a mechanism, we are able to control the gel-sol transition of Fmoc-FFY using the geometric restriction induced by photo-crosslinking of C-terminal tyrosine groups. We believe that geometric restriction should be considered as an important factor in the design of peptide-based materials. It can also be implemented as a useful strategy for the construction of environment-responsive "smart" materials.
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| Keywords:
87.85.Jf
87.85.Jc
87.15.-v
64.75.Yz
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Received: 01 November 2010
Published: 30 January 2011
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| PACS: |
87.85.jf
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(Bio-based materials)
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87.85.jc
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(Electrical, thermal, and mechanical properties of biological matter)
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87.15.-v
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(Biomolecules: structure and physical properties)
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64.75.Yz
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(Self-assembly)
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[1] Whitesides G M and Grzybowski B 2002 Science 295 2418
[2] Lehn J M 2002 Proc. Natl. Acad. Sci. USA 99 4763
[3] Sanchez C, Arribart H and Guille M M 2005 Nature Mater. 4 277
[4] Aizenberg J and Fratzl P 2009 Adv. Mater. 21 387
[5] Ariga K, Hill J P, Lee M V, Vinu A, Charvet R and Acharya S 2008 Sci. Technol. Adv. Mater. 9 014109
[6] Ajayaghosh A, Praveen V K and Vijayakumar C 2008 Chem. Soc. Rev. 37 109
[7] Zhang S 2003 Nature Biotechnol. 21 1171
[8] Gazit E 2007 Chem. Soc. Rev. 36 1263
[9] Vauthey S, Santoso S, Gong H Y, Watson N and Zhang S G 2002 Proc. Natl. Acad. Sci. USA 99 5355
[10] Yang Z, Liang G and Xu B 2008 Acc. Chem. Res. 41 315
[11] Ulijn R V and Smith A M 2008 Chem. Soc. Rev. 37 664
[12] Yan X, Zhu P and Li J 2010 Chem. Soc. Rev. 39 1877
[13] Zelzer M and Ulijn R V 2010 Chem. Soc. Rev. 39 3351
[14] Sedman V L, Adler-Abramovich L, Allen S, Gazit E and Tendler S J 2006 J. Am. Chem. Soc. 128 6903
[15] Palmer L C, Newcomb C J, Kaltz S R, Spoerke E D and Stupp S I 2008 Chem. Rev. 108 4754
[16] Smith A M, Williams R J, Tang C, Coppo P, Collins R F, Turner M L, Saiani A and Ulijn R V 2008 Adv. Mater. 20 37
[17] Yan X H, He Q, Wang K W, Duan L, Cui Y and Li J B 2007 Angew. Chem. Int. Edit. 46 2431
[18] Tamamis P, Adler-Abramovich L, Reches M, Marshall K, Sikorski P, Serpell L, Gazit E and Archontis G 2009 Biophys. J. 96 5020
[19] Yan X H, Cui Y, He Q, Wang K W and Li J B 2008 Chem. Mater. 20 1522
[20] Yan X H, Cui Y, He Q, Wang K W, Li J B, Mu W H, Wang B L and Ou-yang Z C 2008 Chem-Eur J 14 5974
[21] Adler-Abramovich L, Reches M, Sedman V L, Allen S, Tendler S J and Gazit E 2006 Langmuir 22 1313
[22] Hu Y, Wang H, Wang J, Wang S, Liao W, Yang Y, Zhang Y, Kong D and Yang Z 2010 Org. Biomol. Chem. 8 3267
[23] Kol N, Adler-Abramovich L, Barlam D, Shneck R Z, Gazit E and Rousso I 2005 Nano. Lett. 5 1343
[24] Reches M and Gazit E 2006 Nature Nanotechnol. 1 195
[25] Reches M and Gazit E 2003 Science 300 625
[26] Petkova A T, Leapman R D, Guo Z, Yau W M, Mattson M P and Tycko R 2005 Science 307 262
[27] Reches M and Gazit E 2004 Nano. Lett. 4 581
[28] Orbach R, Adler-Abramovich L, Zigerson S, Mironi-Harpaz I, Seliktar D and Gazit E 2009 Biomacromolecules 10 2646
[29] Gao Y A, Zhao F, Wang Q G, Zhang Y and Xu B 2010 Chem. Soc. Rev. 39 3425
[30] Gorbitz C H 2006 Chem. Commun. 2332
[31] Gorbitz C H 2007 Chemistry 13 1022
[32] Du R, Pande V S, Grosberg A Y, Tanaka T and Shakhnovich E 1999 J. Chem. Phys. 111 10375
[33] Zou D W, Tie Z X, Qin M, Lu C M and Wang W 2009 Chin. Phys. Lett. 26 088103
[34] Zou D W, Tie Z X, Lu C M, Qin M, Lu X M, Wang M, Wang W and Chen P 2010 Biopolymers 93 318
[35] Ma M L, Kuang Y, Gao Y, Zhang Y, Gao P and Xu B 2010 J. Am. Chem. Soc. 132 2719
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