Chin. Phys. Lett.  2008, Vol. 25 Issue (1): 321-324    DOI:
Original Articles |
Monte Carlo Simulation on Coordinated Movement of Kinesin and Dynein Motors
WANG Hong;DOU Shuo-Xing;WANG Peng-Ye
Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080
Cite this article:   
WANG Hong, DOU Shuo-Xing, WANG Peng-Ye 2008 Chin. Phys. Lett. 25 321-324
Download: PDF(345KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Abstract Kinesin and dynein are two important classes of molecular motors which are responsible for active organelle trafficking and cell division. They can work together to carry a cargo, moving along the microtubule in a coordinated way. We use Monte Carlo method to simulate the dynamics of this coordinated
movement. Based on four essential assumptions, our simulations reproduce some features of the recent in vivo experiments. The fast moving speed of the cargo is simulated and the speed distribution is presented.
Keywords: 87.16.Nn      87.16.Ac     
Received: 10 April 2007      Published: 27 December 2007
PACS:  87.16.Nn (Motor proteins (myosin, kinesin dynein))  
  87.16.Ac  
TRENDMD:   
URL:  
https://cpl.iphy.ac.cn/       OR      https://cpl.iphy.ac.cn/Y2008/V25/I1/0321
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
WANG Hong
DOU Shuo-Xing
WANG Peng-Ye
[1] Vale R D and Milligan R A 2000 Science 288 88
[2] Hirokawa N and Takemura R 2004 Curr. Opin. Neurobio. 14 564.
[3] Kojima H, Muto E, Higuchi H and Yanagida T 1997 Biophys. J. 73 2012
[4] Snyder G E, Sakamoto T, Hammer J A, Sellers J R and SelvinP R 2004 Biophys. J. 87 1776
[5] Carter N J and Cross R A 2005 Nature 435 308
[6] Mallik R, Carter B C, Lex S A, King S J and Gross S P 2004 Nature 427 649
[7] Toba S, Watanabe T M, Yamaguchi-Okimoto L, Toyoshima Y Yand Higuchi H 2006 Proc. Natl. Acad. Sci. USA 103 5741
[8] Kural C, Kim H, Syed S, Goshima G, Gelfand V I and SelvinP R 2005 Science 308 1469
[9] Gross S P, Welte M A, Block S M and Wieschaus E F 2002 J. Cell Biol. 156 715
[10] Welte M A 2004 Curr. Biol. 14 R525
[11] Babcock H P, Chen C and Zhuang X 2004 Biophys. J. 87 2749
[12] Singh M P, Mallik R, Gross S P and Yu C 2005 Proc.Natl. Acad. Sci. USA 102 12059
[13] Wang H, Dou S X and Wang P Y 2005 Chin. Phys.Lett. 22 2980
[14] Gilbert S P, Webb M R, Brune M and Johnson K A 1995 Nature 373 671
[15] Kon T, Nishiura M, Ohkura R, Toyoshima Y Y and Sutoh K2004 Biochemistry 43 11266
[16] Reck-Peterson S L and Vale R D 2004 Proc. Natl.Acad. Sci. USA 101 1491
[17] Kon T, Mogami T, Ohkura R, Nishiura M and Sutoh K 2005 Nat. Struct. Mol. Biol. 12 513
[18] Mallik R, Petrov D, Lex S A, King S J and Gross S P 2005 Curr. Biol. 15 2075
[19] Reck-Peterson S L, Yildiz A, Carter A P, Gennerich A,Zhang N and Vale R D 2006 Cell 126 335
[20] Welte M A 2004 Curr. Biol. 14 R525
[21] Gross S P 2004 Phys. Biol. 1 R1
[22] Gao Y Q 2006 Biophys. J. 90 811
Related articles from Frontiers Journals
[1] JIANG Li-Guo, WU Heng-An, ZHOU Xiao-Zhou, WANG Xiu-Xi. Coarse-Grained Molecular Dynamics Simulation of a Red Blood Cell[J]. Chin. Phys. Lett., 2010, 27(2): 321-324
[2] HUANG Yan-Bin, PAN Zhang, ZHANG Hui, AN Li, KONG De-Xin, JI Qing. Water in the Neck-Zipper Region of Kinesin[J]. Chin. Phys. Lett., 2009, 26(7): 321-324
[3] SUN Lian-Xiu. Rectification Efficiency of Two Harmonically Coupled Particles[J]. Chin. Phys. Lett., 2009, 26(4): 321-324
[4] TANG Jun, JIA Ya, YI Ming, MA Jun, YU Guang. Coupling Effect of Ion Channel Clusters on Calcium Signalling[J]. Chin. Phys. Lett., 2008, 25(3): 321-324
[5] ZHANG Ji-Qian, HOU Zhong-Huai, XIN Hou-Wen. Neural Signal Tuned by Random Long-range Connections in Coupled FitzHugh--Nagumo Neurons Systems[J]. Chin. Phys. Lett., 2006, 23(9): 321-324
[6] WANG Mao-Sheng, HOU Zhong-Huai, XIN Hou-Wen. System-Size Induced Coherence Resonance in Coupled Minimal Cytosolic Ca2+ Oscillation Models[J]. Chin. Phys. Lett., 2006, 23(2): 321-324
[7] GAO De, JI Qing, Lü Gang. How Is a Protein Molecule Nearsighted?[J]. Chin. Phys. Lett., 2005, 22(9): 321-324
[8] FENG Juan, ZHUO Yi-Zhong,. Master Equation Approach to Molecular Motor’s Directed Motion[J]. Chin. Phys. Lett., 2005, 22(2): 321-324
[9] SHI Xiao-Min, LIU Zeng-Rong. An Intracellular Calcium Oscillations Model Including Mitochondrial Calcium Cycling[J]. Chin. Phys. Lett., 2005, 22(12): 321-324
[10] WANG Hong, DOU Shuo-Xing, WANG Peng-Ye. Monte Carlo Simulation of Kinesin Movement with a Lattice Model[J]. Chin. Phys. Lett., 2005, 22(11): 321-324
[11] JIA Ya, YANG Li-Jian, WU Dan, LIU Quan, ZHAN Xuan. Noise-Induced Bursting and Coherence Resonance in Minimal Cytosolic Ca2+ Oscillation Model[J]. Chin. Phys. Lett., 2004, 21(8): 321-324
[12] YING Yang-Jun, LI Wei-Hua. An Intracellular Calcium Oscillation Model and its Property [J]. Chin. Phys. Lett., 2003, 20(7): 321-324
[13] YING Yang-Jun, HUANG Zu-Qia. Effects of Time-Delay on Intracellular Ca2+ Concentration Oscillations[J]. Chin. Phys. Lett., 2001, 18(5): 321-324
Viewed
Full text


Abstract