| Original Articles |
|
|
|
|
In Vivo Monitoring of Neovascularization in Tumour Angiogenesis by Photoacoustic Tomography |
XIANG Liang-Zhong;XING Da;GU Huai-Min;ZHOU Fei-Fan; YANG Di-Wu;ZENG
Lv-Ming;YANG Si-Hua |
| MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631 |
|
| Cite this article: |
|
XIANG Liang-Zhong, XING Da, GU Huai-Min et al 2007 Chin. Phys. Lett. 24 751-754 |
|
|
|
Abstract Photoacoustic tomography (PAT) is presented to in vivo monitor neovascularization in tumour angiogenesis with high resolution and high
contrast images in a rat. With a circular scan system, the photoacoustic signal, generated by laser pulses at a wavelength of 532nm from a Q-switched Nd:YAG laser, is captured by a hydrophone with a diameter of 1mm and a sensitivity of 850nV/Pa. The vascular structure around the rat tumour is imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. Serial noninvasive photoacoustic images of neovascularization in tumour angiogenesis are also obtained consecutively from a growing tumour implanted under the skin of a rat over a period of two weeks. This work demonstrates that PAT can potentially provide a powerful tool for tumour angiogenesis detection in cancer research. It will bring us closer to clinical applications for tumour diagnosis and treatment monitoring.
|
| Keywords:
43.25.+d
87.57.Ce
43.60.+d
43.80.+p
|
|
|
Received: 04 August 2006
Published: 08 February 2007
|
|
|
|
|
|
|
|
[1] Judah F 1995 Nat. Med. (N.Y.) 1 27
[2] Folkman J 1996 Eur. J. Cancer 32A 2534
[3]Hasan J, Byers R, Jayson G C 2002 Br. J. Cancer 86 1566
[4] Collingridge D R, Carroll V A, Glaser M et al 2002 CancerRes. 62 5912
[5] Knopp M V, von Tengg-Kobligk H and Choyke P L 2003 Mol. CancerTheor. 2 419
[6] Xu X F, Tang Z L and Wang J 2003 Acta Optica Sinica 231103 (in Chinese)
[7] Wang X, Pang Y, Ku G et al 2003 Nature Biotechnol. 21803
[8] Yin B Z, Xing D and Wang Y 2004 Phys. Med. Biol. 491339
[9] Gu H M, Yang S H and Xiang L Z 2006 Prog. Biochem.Biophys. 35 431
[10] Zeng L M, Xing D and Gu H M 2006 Chin. Phys. Lett. 231215
[11] Su Y, Wang R K, Zhang F et al 2006 Chin. Phys. Lett. 23 512
[12] Wang Y, Xing D, Zeng Y G et al 2004 Phys. Med. Biol. 49 3117
[13] Zeng Y G, Xing D and Fu H B 2005 Chin. J. Lasers 32 97
[14] Tan Y, Xing D, Wang Y et al 2005 SPIE 5630 668
[15] Maeda H 2001 Adv. Enzyme. Regul. 41 189
[16] Xiang L Z, Xing D and Gu H M 2006 Acta Phys. Sin.(accepted) (in Chinese)
[17] Yang D W, Xing D and Gu H M 2005 Appl. Phys. Lett. 87194101
[18] Yang D W, Xing D and Tan Y. 2006 Appl. Phys. Lett. 88174101 |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
