Chin. Phys. Lett.  2005, Vol. 22 Issue (12): 3206-3109    DOI:
Original Articles |
An Intracellular Calcium Oscillations Model Including Mitochondrial Calcium Cycling
SHI Xiao-Min1;LIU Zeng-Rong2
1School of Life Science, Shanghai University, Shanghai 200444 2Department of Mathematics, Shanghai University, Shanghai 200444
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SHI Xiao-Min, LIU Zeng-Rong 2005 Chin. Phys. Lett. 22 3206-3109
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Abstract Calcium is a ubiquitous second messenger. Mitochondria contributes significantly to intracellular Ca2+ dynamics. The experiment of Kaftan et al. [J. Biol. Chem. 275(2000) 25465] demonstrated that inhibiting mitochondrial Ca2+ uptake can reduce the frequency of cytosolic Ca2+ concentration oscillations of gonadotropes. By considering the mitochondrial Ca2+ cycling we develop a three-variable model of intracellular Ca2+oscillations based on the models of Atri et al. [Biophys. J. 65 (1993) 1727] and Falcke et al. [Biophys. J. 77 (1999) 37]. The model reproduces the fact that mitochondrial Ca2+ cycling increases the frequency of cytosolic Ca2+ oscillations, which accords with Kaftan's results. Moreover the model predicts that when the mitochondria overload with Ca2+, the cytosolic Ca2+ oscillations vanish, which may trigger apoptosis.
Keywords: 87.16.Ac      87.16.Xa      05.45.a     
Published: 01 December 2005
PACS:  87.16.Ac  
  87.16.Xa (Signal transduction and intracellular signaling)  
  05.45.a  
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https://cpl.iphy.ac.cn/       OR      https://cpl.iphy.ac.cn/Y2005/V22/I12/03206
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