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An Intracellular Calcium Oscillations Model Including Mitochondrial Calcium Cycling |
SHI Xiao-Min1;LIU Zeng-Rong2 |
1School of Life Science, Shanghai University, Shanghai 200444
2Department of Mathematics, Shanghai University, Shanghai 200444 |
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Cite this article: |
SHI Xiao-Min, LIU Zeng-Rong 2005 Chin. Phys. Lett. 22 3206-3109 |
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Abstract Calcium is a ubiquitous second messenger. Mitochondria contributes significantly to intracellular Ca2+ dynamics. The experiment of Kaftan et al. [J. Biol. Chem. 275(2000) 25465] demonstrated that inhibiting mitochondrial Ca2+ uptake can reduce the frequency of cytosolic Ca2+ concentration oscillations of gonadotropes. By considering the mitochondrial Ca2+ cycling we develop a three-variable model of intracellular Ca2+oscillations based on the models of Atri et al. [Biophys. J. 65 (1993) 1727] and Falcke et al. [Biophys. J. 77 (1999) 37]. The model reproduces the fact that mitochondrial Ca2+ cycling increases the frequency of cytosolic Ca2+ oscillations, which accords with Kaftan's results. Moreover the model predicts that when the mitochondria overload with Ca2+, the cytosolic Ca2+ oscillations vanish, which may trigger apoptosis.
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Keywords:
87.16.Ac
87.16.Xa
05.45.a
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Published: 01 December 2005
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