Chin. Phys. Lett.  2018, Vol. 35 Issue (5): 058701    DOI: 10.1088/0256-307X/35/5/058701
 CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
Human Pulmonary Hyperpolarized $^{129}$Xe MRI: a Preliminary Study
Hao Yang1, Ke Wang1, Hui-Ting Zhang2, Jun-Shuai Xie2, Guang-Yao Wu1**, Xin Zhou2**
1The Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071
2State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071
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Abstract We study the feasibility and safety of human lung hyperpolarized (HP) $^{129}$Xe magnetic resonance imaging (MRI). There is no significant change in physiological parameters before and after the examinations of all subjects. Compared with computed tomography, HP $^{129}$Xe MRI is sensitive to earlier and smaller ventilation defects. The distribution of the HP $^{129}$Xe MRI signal reflects the pulmonary compliance with the gravity gradient. This is the first application of HP $^{129}$Xe MRI ventilation imaging in China, and this technology is expected to provide more useful information for clinical practice.
Received: 29 September 2017      Published: 30 April 2018
 PACS: 87.80.Lg (Magnetic and paramagnetic resonance) 51.60.+a (Magnetic properties) 28.20.Pr (Neutron imaging; neutron tomography)
Fund: Supported by the National Natural Science Foundation of China under Grant Nos 81227902 and 81625011, the National Key Research and Development Program of China under Grant No 2016YFC1304702, and the Key Research Program of Frontier Sciences of CAS (QYZDY-SSW-SLH018).
 Cite this article: Hao Yang, Ke Wang, Hui-Ting Zhang et al  2018 Chin. Phys. Lett. 35 058701 URL: http://cpl.iphy.ac.cn/10.1088/0256-307X/35/5/058701       OR      http://cpl.iphy.ac.cn/Y2018/V35/I5/058701